Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Xueyan FuJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Boston MA USA.
M Kyla SheaJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Boston MA USA.
Russell TracyUniversity of Vermont Larner College of Medicine Burlington VA USA.ORCID 0000-0002-0080-2420
Matthew BudoffDivision of Cardiology The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center Torrance CA USA.ORCID 0000-0002-9616-1946
Ryung S KimDepartment of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA.ORCID 0000-0002-9603-7726
Mahim NaveedDepartment of Medicine, Division of Cardiology San Francisco VA Health Care System San Francisco CA USA.ORCID 0000-0001-7434-7654
Sarah L BoothJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Boston MA USA.ORCID 0000-0002-1525-4025
Jorge R KizerDepartment of Medicine, Division of Cardiology San Francisco VA Health Care System San Francisco CA USA.ORCID 0000-0001-9936-7803
Anna E BortnickDepartment of Medicine, Division of Cardiology Montefiore Medical Center and Albert Einstein College of Medicine Bronx NY USA.ORCID 0000-0001-7983-5243
Funding
CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patientsUL1TR002556 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, KIM, MIMI Y · 2018 to 2022
$26.7M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Einstein-Montefiore Clinical and Translational Science Award HubUM1TR004400 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Jessica Kahn, Mimi Y Kim · 2023 to 2026
$17.3M
The VMH and Molecular Control of Energy BalanceR01DK071051 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2005 to 2014
$3.7M
Coronary Artery Calcium, Aortic Calcification and Density in MESAR01HL146666 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI BUDOFF, MATTHEW J · 2020 to 2023
$3.0M
Ventricular Size and Valve Calcification Measures by CTR01HL071739 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI BUDOFF, MATTHEW J · 2003 to 2010
$2.0M
MESA Family StudyR01HL071250 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, KIANG JOHN · 2003 to 2007
$991k
Genome-wide and Linkage Study of Quantitative Emphysema PhenotypesRC1HL100543 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARR, R GRAHAM, RICH, STEPHEN S. · 2009 to 2010
$970k
Cardiac Calcification and Cholesterol Efflux in Older AdultsK23HL146982 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BORTNICK, ANNA E · 2020 to 2024
$951k
MESA Family StudyR01HL071251 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PANKOW, JAMES S · 2003 to 2007
$844k
CULTURAL STRATEGIES FOR PREVENTING CONDUCT PROBLEMSK01MH001881 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COARD, STEPHANIE I · 2000 to 2004
$597k
Bidirectional relationships between positive and negative social media use and suicidal ideation in high-risk adolescentsR21MH135493 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI HAMILTON, JESSICA LEIGH · 2024 to 2024
backgroundMGP (matrix Gla protein) inhibits arterial calcification. Higher inactive MGP, in its dephosphorylated-uncarboxylated (dp-uc) form, is positively associated with vascular calcification, possibly portending adverse cardiovascular events. The objective of this study was to determine the association of dp-ucMGP with incident cardiovascular disease (CVD) events and mortality in MESA (Multi-Ethnic Study of Atherosclerosis).
methodsMESA is a prospective cohort study of 45- to 84-year-old individuals enrolled between 2000 and 2002 with adjudicated outcomes through 2019. Dp-ucMGP was measured at baseline in n=2663 participants with cardiac computed tomography at Exams 1 (2000-2002) and 5 (2010-2012). Age-stratified Cox proportional hazard models were used to assess dp-ucMGP with risk of all CVD (mean follow-up 16±4 years), hard CVD (17±3 years), hard coronary heart disease (17±3 years), and all-cause mortality (18±2 years).
resultsThe youngest age quartile (45- to 53-years-old) with higher dp-ucMGP levels (520-2934 pmol/L) had an increased risk of all CVD (hazard ratio [HR], 3.05 [95% CI, 1.58-5.90],
conclusionsYounger individuals 45 to 53 years old with elevated dp-ucMGP levels (≥520 pmol/L) had an increased risk of incident CVD, coronary heart disease, and all-cause mortality. No association was seen in older adults. Additional studies are needed to better delineate the relationship of inactive MGP with incident CVD, coronary heart disease, and all-cause mortality.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Inactive Matrix Gla Protein and Cardiovascular Outcomes: The Multi-Ethnic Study of Atherosclerosis. · full record | Socratic