Evidence map›Paper›PMID 39970001›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Nongenetic adaptation by collective migration.

Lam Vo, Fotios Avgidis, Henry H Mattingly, Karah Edmonds, Isabel Burger, Ravi Balasubramanian, Thomas S Shimizu, Barbara I Kazmierczak, Thierry Emonet

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Growth-dependent sensory bet-hedging enhances collective navigation.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Spatial self-organization of confined bacterial suspensions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Role of a single MCP in evolutionary adaptation ofApplied and environmental microbiology · 2025
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Lam Vo *Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511.ORCID 0000-0003-1008-9101
Fotios Avgidis *Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511.ORCID 0000-0002-8580-7916
Henry H Mattingly *Center for Computational Biology, Flatiron Institute, New York City, NY 10010.ORCID 0000-0001-7143-0276
Karah EdmondsDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511.
Isabel BurgerDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511.
Ravi BalasubramanianDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511.
Thomas S ShimizuCenter for Living Systems, AMOLF Institute, Amsterdam 1098 XG, The Netherlands.ORCID 0000-0003-0040-7380
Barbara I KazmierczakDepartments of Medicine and Microbial Pathogenesis, Yale University, New Haven, CT 06511.ORCID 0000-0002-8162-803X
Thierry EmonetDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511.ORCID 0000-0002-6746-6564

Funding

The contribution of phenotypic variability to chemotactic performanceR01GM106189 · NIGMS · YALE UNIVERSITY · PI EMONET, THIERRY · 2013 to 2022
$2.6M
Spontaneous Organization of Phenotypes during Collective MigrationR01GM138533 · NIGMS · YALE UNIVERSITY · PI EMONET, THIERRY · 2020 to 2023
$1.3M
Spatial organization of phenotypically diverse cells during collective migrationF31GM149174 · NIGMS · YALE UNIVERSITY · PI VO, LAM · 2023 to 2025
$146k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) F31GM149174-01HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM106189HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM138533NIGMS NIH HHS F31 GM149174NIGMS NIH HHS R01 GM106189NIGMS NIH HHS R01 GM138533
6 · The paper itself

Abstract

Cell populations must adjust their phenotypic composition to adapt to changing environments. One adaptation strategy is to maintain distinct phenotypic subsets within the population and to modulate their relative abundances via gene regulation. Another strategy involves genetic mutations, which can be augmented by stress-response pathways. Here, we studied how a migrating bacterial population regulates its phenotypic distribution to traverse diverse environments. We generated isogenic

Indexed as

Adaptation, PhysiologicalChemotaxisEscherichia coliEscherichia coli ProteinsPhenotypeEscherichia coli Proteinsbacterial chemotaxiscollective behaviormicrobial ecologynon-genetic diversitypopulation-level adaptation

Identifiers

PMID39970001
PMCPMC11874451

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.