Evidence map›Paper›PMID 39970249›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Clonal Hematopoiesis Increases Hypertension and Sympathetic Activity and Is Reversed by Renal Denervation.

Ariel H Polizio, Lucila Marino, Luca Rolauer, Heather Doviak, Maria Grandoch, Stefano Toldo, Kenneth Walsh

Abstract readLetter
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The sympathetic nervous system in the pathophysiology of hypertension: Mechanistic insights and therapeutic implications.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ariel H PolizioCardiovascular Medicine and the Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville (A.H.P., L.M., H.D., S.T., K.W.).ORCID 0000-0001-5413-7238
Lucila MarinoCardiovascular Medicine and the Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville (A.H.P., L.M., H.D., S.T., K.W.).
Luca RolauerInstitute of Translational Pharmacology and Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany (L.R., M.G.).
Heather DoviakCardiovascular Medicine and the Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville (A.H.P., L.M., H.D., S.T., K.W.).ORCID 0000-0002-0720-3164
Maria GrandochInstitute of Translational Pharmacology and Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany (L.R., M.G.).ORCID 0000-0002-4382-1947
Stefano ToldoCardiovascular Medicine and the Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville (A.H.P., L.M., H.D., S.T., K.W.).ORCID 0000-0002-1588-4019
Kenneth WalshCardiovascular Medicine and the Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville (A.H.P., L.M., H.D., S.T., K.W.).ORCID 0000-0001-7580-2276

Funding

Wnt signaling control of vascular phenotype in obesityR01HL142650 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, WALSH, KENNETH · 2019 to 2023
$3.1M
Mosaic loss of Y chromosome in blood and heart failureR01AG073249 · NIA · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2021 to 2025
$2.6M
Modeling of cell-specific LRP1 signaling in acute myocardial infarctionR01HL174999 · NHLBI · UNIVERSITY OF VIRGINIA · PI Antonio Abbate, Jeffrey J. Saucerman · 2024 to 2026
$2.3M
Role of therapy-related clonal hematopoiesis in anthracycline-induced cardiotoxicityR01HL152174 · NHLBI · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2020 to 2024
$2.0M
Unconventional IL-1 Signaling in Heart failureR01HL150115 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI ABBATE, ANTONIO, TOLDO, STEFANO · 2020 to 2024
$1.9M
Muscle loss and metabolic dysfunction associated with agingR01AG034972 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALSH, KENNETH · 2010 to 2014
$1.6M
NHLBI NIH HHS R01 HL142650NHLBI NIH HHS R01 HL150115NHLBI NIH HHS R01 HL152174NHLBI NIH HHS R01 HL174999NIA NIH HHS R01 AG034972NIA NIH HHS R01 AG073249
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

autonomic denervationclonal hematopoiesishypertensioninflammasomeskidneysympathetic nervous system

Identifiers

PMID39970249
PMCPMC12108919

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.