Evidence map›Paper›PMID 39971735›Full record

ReviewFEMS microbiology reviews2025

Evolving spectrum of Pneumocystis host specificity, genetic diversity, and evolution.

Liang Ma, Christiane Weissenbacher-Lang, Alice Latinne, Spenser Babb-Biernacki, Barbara Blasi, Ousmane H Cissé, Joseph A Kovacs

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Antioxidants (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liang MaCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, United States.ORCID 0000-0002-6078-5730
Christiane Weissenbacher-LangDepartment of Biological Sciences and Pathobiology, Institute of Pathology, University of Veterinary Medicine Vienna, Vienna 1210, Austria.
Alice LatinneWildlife Conservation Society, Melanesia Program, Suva, Fiji.
Spenser Babb-BiernackiDepartment of Biology, Louisiana State University, Baton Rouge, LA 70803, United States.
Barbara BlasiDepartment of Biological Sciences and Pathobiology, Institute of Pathology, University of Veterinary Medicine Vienna, Vienna 1210, Austria.
Ousmane H CisséCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, United States.
Joseph A KovacsCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, United States.

Funding

NIH HHSUniversity of Veterinary Medicine, Vienna
6 · The paper itself

Abstract

Following over a century's worth of research, our understanding of Pneumocystis has significantly expanded in various facets, spanning from its fundamental biology to its impacts on animal and human health. Its significance in public health has been underscored by its inclusion in the 2022 WHO fungal priority pathogens list. We present this review to summarize pivotal advancements in Pneumocystis epidemiology, host specificity, genetic diversity and evolution. Following a concise discussion of Pneumocystis species classification and divergence at the species and strain levels, we devoted the main focus to the following aspects: the epidemiological characteristics of Pneumocystis across nearly 260 mammal species, the increasing recognition of coinfection involving multiple Pneumocystis species in the same host species, the diminishing host specificity of Pneumocystis among closely related host species, and the intriguingly discordant evolution of certain Pneumocystis species with their host species. A comprehensive understanding of host specificity, genetic diversity, and evolution of Pneumocystis can provide important insights into pathogenic mechanisms and transmission modes. This, in turn, holds the potential to facilitate the development of innovative strategies for the prevention and control of Pneumocystis infection.

Indexed as

Evolution, MolecularGenetic VariationHost SpecificityPneumocystisPneumocystis InfectionsAnimalsBiological EvolutionHumanscoinfectioncross-species infectionepidemiologyevolutiongenetic diversityhost specificityPneumocystis

Identifiers

PMID39971735
PMCPMC11916894

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.