Evidence map›Paper›PMID 39971835›Full record

ArticleBiochemical genetics2026

Identification and Co-expression Analysis of Differentially Expressed LncRNAs and mRNAs Regulate Intramuscular Fat Deposition in Yaks at Two Developmental Stages.

Zhanhong Gao, Quyangangmao Su, Sayed Haidar Abbas Raza, Cristian Piras, Mona N BinMowyna, Majid Al-Zahrani, Charalampos Mavromatis, Raafat T M Makhlof, Mustafa M Senna, Linsheng Gui

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Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Zhanhong Gao *College of Agriculture and Animal Husbandry, Qinghai University, Xining, 810016, Qinghai, People's Republic of China.
Quyangangmao Su *College of Agriculture and Animal Husbandry, Qinghai University, Xining, 810016, Qinghai, People's Republic of China.
Sayed Haidar Abbas RazaGuangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou, 510642, China.
Cristian PirasDepartment of Health Sciences, Magna Græcia University of Catanzaro, 88100, Catanzaro, Italy.
Mona N BinMowynaCollege of Education, Shaqra University, 11911, Shaqra, Saudi Arabia.
Majid Al-ZahraniDepartment of Biological Sciences, College of Science and Arts, King Abdulaziz University, P.O. Box 344, 21911 Rabigh, Saudi Arabia.
Charalampos MavromatisDepartment of Biological Sciences, College of Science and Arts, King Abdulaziz University, P.O. Box 344, 21911 Rabigh, Saudi Arabia.
Raafat T M MakhlofDepartment of Parasitology, Faculty of Medicine, Umm Al Qura University, P.O. Box 715, 21955, Makkah, Saudi Arabia.
Mustafa M SennaDepartment of Anatomy, Faculty of Medicine, Umm-Alqura University, Makkah, Saudi Arabia.
Linsheng GuiCollege of Agriculture and Animal Husbandry, Qinghai University, Xining, 810016, Qinghai, People's Republic of China. 2017990039@qhu.edu.cn.

Funding

The research was supported by the National Natural Science Foundation of China (No: 31960649). 31960649
6 · The paper itself

Abstract

Intramuscular fat (IMF) content is a key indicator of yak meat quality. This study aimed to identify lncRNAs that regulate IMF deposition in yaks. Three male calf yaks (3 months) and three male adult yaks (3 years) were used in the current study. After slaughter, the tissue morphology of the longissimus dorsi (LD) muscle was assessed using a cry-sectioning technique and differentially expressed lncRNAs and mRNAs (DELs and DEMs) were identified using RNA-Seq technology. The diameter and volume of fat droplets were significantly larger and bigger, respectively, in adults than in calves (P < 0.001). A total of 37,790 genes and 16,400 lncRNAs that regulate fat deposition were identified. Among them, 2327 mRNAs and 474 lncRNAs were differentially expressed between calves and adult yaks. DEGs stearoyl-CoA desaturase (SCD), fatty acid synthase (FASN), fatty acid binding protein 4 (FABP4) and fibronectin 1 (FN1) and DELs MSTRG.15795.4 and MSTRG.35028.6 were screened. The enrichment and pathway analysis regulated by the DMEs and DELs were predicted. We found significantly enriched biological processes and pathways involved in fat deposition, including the biosynthesis of unsaturated fatty acids, fatty acid biosynthesis, fatty acid elongation, and the mTOR signaling pathway. Co-expression network of the DELs and related genes, including MSTRG.10268.1-placenta associated 8 (PLAC8), MSTRG.16223.1-galectin 3 (LGALS3), MSTRG.34732.1-glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), MSTRG.11907.11-fibroblast growth factor 1 (FGF1), MSTRG.34342.1-lipase A, lysosomal acid type (LIPA), and MSTRG.1667.2-integrin subunit beta 2 (ITGB2) was constructed. RT-qPCR verified the sequence results. The molecular regulatory mechanisms of lncRNAs on intramuscular fat deposition in yak were further explored.

Indexed as

Adipose TissueGene Expression Regulation, DevelopmentalMuscle, SkeletalRNA, Long NoncodingRNA, MessengerAnimalsCattleGene Expression ProfilingMaleRNA, Long NoncodingRNA, MessengerDevelopmental stagesIntramuscular fat depositionLncRNAmRNAYak

Identifiers

PMID39971835

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.