Evidence map›Paper›PMID 39972309›Full record

ArticleBMC geriatrics2025

Associations between neutrophil-lymphocyte ratio and risk of cognitive impairment among Chinese older adults.

Xin Wang, Binbin Wang, Xueqing Du, Peng Liu, Fuwen Yang, Jiao Su, Yue Zhang

Abstract read
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Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Neutrophil-to-Lymphocyte Ratio in the Alzheimer's Disease Continuum.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xin WangDepartment of Neurology, Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Binbin WangSchool of Life Science, Shanxi Normal University, Taiyuan, China.
Xueqing DuDepartment of Neurology, Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Peng LiuDepartment of Cardiovascular Surgery, The Affiliated Hospital of Shanxi Medical University, Shanxi Cardiovascular Hospital (Institute), Taiyuan, China.
Fuwen YangDepartment of Neurology, Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Jiao SuDepartment of Neurology, Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Yue ZhangSchool of Public Health, Department of Epidemiology, Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Ministry Education, Taiyuan, China. yuezhang@sxmu.edu.cn.

Funding

National Natural Science Foundation of China 82401694the National Natural Science Foundation of China 32101923the Natural Science Foundation for Young Scientists of Shanxi Province 20210302124066the Natural Science Foundation for Young Scientists of Shanxi Province 202303021212339the Shanxi Bethune Hospital Talent Introduction Research 2023RC14
6 · The paper itself

Abstract

backgroundAssociations between the neutrophil-lymphocyte ratio (NLR) and cognitive performance in older population are rarely reported. We investigated the associations between NLR and risk of cognitive impairment in Chinese community-dwelling older adults.

methodsIndividuals aged ≥ 65 years from the 2011 and 2014 waves of the Chinese Longitudinal Healthy Longevity Survey were enrolled. We used the Chinese version of the Mini-Mental State Examination to evaluate cognitive function, with a score <18 indicating cognitive impairment. NLR was expressed as derived NLR (white blood cell count - lymphocyte count]/lymphocyte count). Logistic regression was used to evaluate the association between NLR levels and risk of cognitive impairment.

resultsThe study enrolled 2375 cognitively healthy participants and 838 with cognitive impairment. Significantly higher NLR values were noted in the latter than in the former group. In the cross-sectional analysis, NLR values in the highest than in the lowest quartile indicated significantly increased risk of cognitive impairment, after controlling for all confounding factors. During follow-up, 134 of the 1173 healthy participants at baseline developed cognitive impairment. NLR values in the highest two quartiles indicated higher risk of cognitive impairment than those in the lowest quartile. When NLR was classified into dichotomous groups, the risk of cognitive impairment was significantly higher in the high-inflammation than in the noninflammatory status group, regardless of the analysis used (cross-sectional or prospective).

conclusionsElevated NLR status is associated with increased risk of cognitive impairment in Chinese community-dwelling older adults.

Indexed as

Cognitive DysfunctionLymphocytesNeutrophilsAgedAged, 80 and overChinaCross-Sectional StudiesEast Asian PeopleFemaleFollow-Up StudiesHumansLeukocyte CountLongitudinal StudiesLymphocyte CountMaleRisk FactorsAlzheimer’s diseaseCognitive impairmentInflammationNeutrophil–lymphocyte ratioOlder adults

Identifiers

PMID39972309
PMCPMC11841232

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.