Evidence map›Paper›PMID 39972425›Full record

ArticleBMC cardiovascular disorders2025

The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction.

Lingmiao Wang, Ailin Guo, Shuang Liang, Lingling Yu, Bai Shen, Zhihang Huang

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lingmiao WangDepartment of Anesthesiology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, No.2000 Xiang'an East Road, Xiamen, 361101, China.
Ailin GuoDepartment of Cardiovascular Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, No.2000 Xiang'an East Road, Xiamen, 361101, China.
Shuang LiangDepartment of Cardiovascular Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, No.2000 Xiang'an East Road, Xiamen, 361101, China.
Lingling YuDepartment of Cardiovascular Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, No.2000 Xiang'an East Road, Xiamen, 361101, China.
Bai ShenDepartment of Cardiovascular Medicine, Dongguan Songshan Lake Central Hospital, Dongguan Institute of Cardiovascular Disease, No.1 Xianglong Road, Shilong Town, Dongguan, 523326, China. yi111_2@163.com.
Zhihang HuangDepartment of Cardiovascular Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, No.2000 Xiang'an East Road, Xiamen, 361101, China. yi134_9@163.com.

Funding

Fujian Provincial Natural Science Foundation social development science and technology guiding project No. 2022D035Science and Technology Project of Xiamen Municipal Bureau of Science and Technology No. 3502Z20214ZD1129
6 · The paper itself

Abstract

backgroundHeart failure poses a huge burden on the global population, and approximately 50% cases have reduced ejection fraction, namely, heart failure with reduced ejection fraction (HFrEF). The research was supposed to explore the relationship between serum hsa-miR-21-5p expression and the severity/prognosis of HFrEF.

methodsA retrospective analysis was conducted on 105 HFrEF patients and 86 healthy volunteers. RT-qPCR was used for the detection of serum hsa-miR-21-5p levels. Whether serum hsa-miR-21-5p expression correlated to cardiac function and hemodynamic indicators was evaluated using Spearman correlation analysis. Receiver operating characteristic and Kaplan-Meier analyses were implemented to evaluate the predictive significance of serum hsa-miR-21-5p for cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients. Independent risk factors for cardiovascular deaths were analyzed based on COX regression.

resultsHigher heart rate, fasting plasma glucose (FPG), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), left atrial diameter (LAD), systolic pulmonary artery pressure (sPAP), pulmonary vascular resistance (PVR), pulmonary capillary wedge pressure (PCWP), and hsa-miR-21-5p as well as lower left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were detected in the HFrEF patients than in the controls. Hsa-miR-21-5p expression increased in HFrEF patients with the increase of NYHA grade. Serum hsa-miR-21-5p expression in HFrEF patients was positively relevant to NT-pro-BNP, LAD, sPAP, PVR, and PCWP but negatively related to LVEF and LVFS. Serum hsa-miR-21-5p had a high predictive value for cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients. High hsa-miR-21-5p expression was an independent dangerous factor for cardiovascular deaths.

conclusionCollectively, hsa-miR-21-5p expression in HFrEF patients is correlated with disease severity and the risk of cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients, indicating a new direction for evaluating the disease situation and prognosis.

Indexed as

Circulating MicroRNAHeart FailureMicroRNAsStroke VolumeVentricular Function, LeftAgedBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedPatient ReadmissionPredictive Value of TestsPrognosisRetrospective StudiesBiomarkersCirculating MicroRNAMicroRNAsMIRN21 microRNA, humanCardiac functionCardiovascular deathsCardiovascular re-hospitalizationDisease severityHeart failure with reduced ejection fractionHsa-miR-21-5pNYHA gradePrognosis

Identifiers

PMID39972425
PMCPMC11837298

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.