Evidence map›Paper›PMID 39973006›Full record

Trial reportObesity (Silver Spring, Md.)2025

Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial.

Niki Oldenburg, Douglas G Mashek, Lisa Harnack, Qi Wang, Emily N C Manoogian, Nicholas Evanoff, Donald R Dengel, Abdisa Taddese, Brad P Yentzer, Lesia Lysne and 14 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Niki OldenburgDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Douglas G MashekDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Lisa HarnackSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Qi WangClinical and Translational Science Institute, University of Minnesota, Minneapolis, Minnesota, USA.
Emily N C ManoogianSalk Institute for Biological Sciences, San Diego, California, USA.
Nicholas EvanoffCollege of Education and Human Development, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-5616-5857
Donald R DengelCollege of Education and Human Development, University of Minnesota, Minneapolis, Minnesota, USA.
Abdisa TaddeseDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Brad P YentzerDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Lesia LysneDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Alison WongDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Michelle HansonDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Julie D AndersonDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Alison AlvearDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Nicole LaPageDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Justin RyderDepartment of Surgery, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Krista VaradyCollege of Applied Health Sciences, University of Illinois, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-9279-9934
Zan GaoCollege of Education, Health, and Human Sciences, University of Tennessee, Knoxville, Tennessee, USA.
Suryeon RyuCollege of Education and Human Development, University of Minnesota, Minneapolis, Minnesota, USA.
Patrick J BolanDepartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Bryan BergmanSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Erika HelgesonSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Satchidananda PandaSalk Institute for Biological Sciences, San Diego, California, USA.
Lisa S ChowDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-6210-2307

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
Prolonged Daily Fasting As a Viable Alternative to Caloric Restriction in At-Risk Obese HumansR01DK124484 · NIDDK · UNIVERSITY OF MINNESOTA · PI CHOW, LISA SENYE · 2020 to 2023
$2.7M
High Performance Connectome Upgrade for Human 3T MR ScannerS10OD017974 · OD · UNIVERSITY OF MINNESOTA · PI LIM, KELVIN O. · 2014 to 2014
$600k
DexcomNCATS NIH HHS UM1 TR004405NIBIB NIH HHS P41 EB027061NIDDK NIH HHS P41EB027061NIDDK NIH HHS R01 DK124484NIDDK NIH HHS R01DK124484NIDDK NIH HHS S10OD017974NIH HHS S10 OD017974Robert Wood Johnson Foundation 76014UMN CTSA Award UM1TR004405
6 · The paper itself

Abstract

objectiveMetabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.

methodsIn this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).

resultsOf the 88 enrolled participants, 81 (92%) completed the trial (mean [SD], age, 43.2 [10.5] years, BMI, 36.2 [5.1] kg/m

conclusionsIn a 12-week intervention, TRE did not lead to significant improvements in weight, average body composition, or glycemic or metabolic measures compared with CR or UE.

Indexed as

Body WeightCaloric RestrictionFastingObesityWeight LossAbsorptiometry, PhotonAdultBlood GlucoseBody CompositionBody Mass IndexEnergy IntakeEnergy MetabolismFemaleGlucose Clamp TechniqueGlycated HemoglobinHumansBlood GlucoseGlycated Hemoglobin

Identifiers

PMID39973006
PMCPMC11937878

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.