Evidence map›Paper›PMID 39973015›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2026

Towards the Development of a Conceptual Framework of the Determinants of Pre-Eclampsia: A Hierarchical Systematic Review of Social Determinants.

Mai-Lei Woo Kinshella, Kelly Pickerill, Sarina Prasad, Olivia Campbell, Jalila Devji, Lívia Vieira Lopes, Rosa Balleny, Terteel Elawad, Rachel Craik, Marie-Laure Volvert and 7 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Determinants of Pre-Eclampsia: Advancing a Conceptual Framework.BJOG : an international journal of obstetrics and gynaecology · 2026
    Article
  5. Review
  6. FIGO committee opinion: Environmental drivers of obstetric health and early childhood development.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  7. Observational
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mai-Lei Woo KinshellaDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0001-5846-3014
Kelly PickerillDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Sarina PrasadDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Olivia CampbellDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Jalila DevjiDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Lívia Vieira LopesDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Rosa BallenyDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Terteel ElawadDepartment of Women and Children's Health, School of Life Course and Population Sciences, Kings College London, London, UK.
Rachel CraikDepartment of Women and Children's Health, School of Life Course and Population Sciences, Kings College London, London, UK.ORCID https://orcid.org/0000-0001-7885-0775
Marie-Laure VolvertDepartment of Women and Children's Health, School of Life Course and Population Sciences, Kings College London, London, UK.
Hiten D MistryDepartment of Women and Children's Health, School of Life Course and Population Sciences, Kings College London, London, UK.
Hannah BlencoweFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Véronique FilippiFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Peter von DadelszenDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0003-4136-3070
Laura A MageeDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0002-1355-610X
Marianne VidlerDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
PRECISE Network

Funding

UK Research and InnovationWellcome Trust 217123
6 · The paper itself

Abstract

backgroundExisting reviews of pre-eclampsia determinants have focused on clinical and genetic risk factors.

objectiveTo evaluate social determinants for pre-eclampsia prevention. SEARCH STRATEGY: Systematic searches were conducted from relevant electronic databases from inception of each database to 30th December 2024. SELECTION CRITERIA: Reviews and large cohort studies (≥ 1000 participants), published between 2013 and 2024, reporting quantitative associations between social determinant exposures and pre-eclampsia outcomes. DATA COLLECTION AND ANALYSIS: Titles and abstracts, then relevant full-texts were reviewed by two reviewers, independently. Strength of association was evaluated as 'definite' (odds ratios [OR] or relative risk [RR] ≥ 3.00 or < 0.33), 'probable' (OR or RR 1.50-2.99 or 0.33-0.67), 'possible' (OR or RR 1.10-1.49 or 0.68-0.89), or 'unlikely' (OR or RR 0.90-1.09). Quality of the evidence was high, moderate, low, or very-low, using GRADE. MAIN

resultsTwenty-seven publications found 24 associations of pre-eclampsia with socioeconomic status, social support/exclusion, healthcare access, and occupational and physical environmental factors. One association (polygamy) was definite (low-quality evidence). Probable associations included: work stress, lack of antenatal care and heat exposure in early pregnancy (high-quality evidence); prolonged occupational exposure to whole body vibrations or bending, distance to health facility, and UV-B radiation exposure (protective factor), all based on moderate-quality evidence; and neighbourhood deprivation, rotating work shifts, and Asian/Oceanian origins (protective factor), all based on low-quality evidence. There were 13 possible associations, which did not include education.

conclusionOur findings support recommendations to address climate change, strengthen occupational protection, and promote early antenatal attendance. Social determinants may be indicative of upstream factors (e.g., obesity) that increase likelihood of clinical risk factors for pre-eclampsia incidence and severity.

Indexed as

Pre-EclampsiaSocial Determinants of HealthFemaleHumansPregnancyRisk FactorsSocial Support

Identifiers

PMID39973015
PMCPMC7618191

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.