Evidence map›Paper›PMID 39973503›Full record

Trial reportJournal of Parkinson's disease2025

Effects of 6 months of endurance exercise on motor function, exercise capacity, and autonomic function based on presence of autonomic dysfunction in individuals with early Parkinson's disease.

Garett J Griffith, Niyati Mehta, Guillaume Lamotte, Kathleen E McKee, Erin Suttman, Jacob M Haus, Elizabeth Joslin, Katherine Balfany, Wendy M Kohrt, Cory L Christiansen and 5 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Physical Activity and Exercise for People with Parkinson's Disease: The Past, Present, and Future.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Garett J GriffithDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-4243-6676
Niyati MehtaDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-5453-6415
Guillaume LamotteDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-4048-6095
Kathleen E McKeeIntermountain Health, Neurosciences Clinical Program, Salt Lake City, UT, USA.ORCID 0000-0002-8354-151X
Erin SuttmanDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-1515-1931
Jacob M HausSchool of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
Elizabeth JoslinDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Katherine BalfanySchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0009-0001-8164-8671
Wendy M KohrtSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cory L ChristiansenSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-3273-1169
Edward L MelansonSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-9151-9745
Lana M ChahineDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Demetra D ChristouDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Charity G PattersonDepartment of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0060-0124
Daniel M CorcosDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-7440-6458

Funding

Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3U01NS113851 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniel M. Corcos · 2019 to 2026
$29.6M
Exploratory study of different doses of endurance exercise in people with ParkinsR01NS074343 · NINDS · UNIVERSITY OF COLORADO DENVER · PI CORCOS, DANIEL M., SCHENKMAN, MARGARET L · 2011 to 2014
$3.0M
Research Training in Sensorimotor NeurorehabilitationT32HD101395 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2021 to 2025
$1.7M
NICHD NIH HHS T32 HD101395NINDS NIH HHS R01 NS074343NINDS NIH HHS U01 NS113851
6 · The paper itself

Abstract

BackgroundEndurance exercise improves aerobic capacity (VO

Indexed as

Autonomic Nervous System DiseasesEndurance TrainingExercise TherapyExercise ToleranceOutcome Assessment, Health CareParkinson DiseaseAgedFemaleHeart RateHumansMaleMiddle AgedOxygen Consumptionaerobic capacitychronotropic incompetenceendurance exercisemotor symptoms

Identifiers

PMID39973503
PMCPMC13347429

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.