ArticlemedRxiv : the preprint server for health sciences2025
Network changes associated with right anterior temporal lobe atrophy: insight into unique symptoms.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Semantic behavioral variant (also referred to as right temporal) frontotemporal dementia is a newly described syndrome associated with focal right anterior temporal lobe atrophy and a distinctive combination of behavioral and semantic changes. It is considered the right-sided counterpart of semantic variant primary progressive aphasia, with which it has overlapping neuropathological and cognitive mechanisms. Although more is known about how brain network alterations relate to both losses (e.g., word comprehension deficits) and gains (e.g., hyper-fluency) in cognitive and behavioral processes in the left-sided semantic progressive aphasia, less is known about these phenomena in the right-sided semantic behavioral variant. In this study, we investigated functional connectivity within the right counterparts of established ventral and dorsal cortical speech and language networks and their relationship to specific clinical manifestations in individuals with the semantic behavioral variant. We hypothesized that socioemotional-semantic deficits would be associated with reduced connectivity in the right ventral semantic network, while heightened behavioral manifestations, such as hyper-focus on specific interests (also referred to as rigidity), would be associated with increased connectivity in the right dorsal network. Using seed-based intrinsic connectivity analyses of fMRI data and cognitive scores from 22 individuals with semantic behavioral variant frontotemporal dementia and 48 cognitively normal individuals, we measured intrinsic connectivity strength in networks anchored in the right anterior middle temporal gyrus (ventral network) and in the right opercular inferior frontal gyrus (dorsal network). Functional connectivity values were then correlated with cognitive and behavioral measurements, controlling for global atrophy. Compared to the control group, individuals with semantic behavioral variant exhibited reduced connectivity in the ventral network (
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