ReviewFrontiers in endocrinology2025
Mechanisms of oxidative stress-induced sperm dysfunction.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
165 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of astaxanthin efficacy in male infertility: evidence from clinical and preclinical studies.Scientific reports · 2026Pooled it
- Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- New Insights from Toxinology in Mammalian Reproduction: A Systematic Review.Mini reviews in medicinal chemistry · 2025Pooled it
- An automatic semen processing system versus a manual method for semen processing: a randomized, single-blind non-inferiority trial.Frontiers in endocrinology · 2026Trial
- Improving the cryo-resistance of Egyptian buffalo semen via chlorogenic acid and rutin supplementation: molecular docking, antioxidant, and anti-apoptotic pathways.BMC veterinary research · 2026Article
- Proteomic Landscape of Spermatozoa Under Inflammatory and Oxidative Injury: Molecular Mechanisms and Clinical Translation.Antioxidants (Basel, Switzerland) · 2026Review
- Seminal ubiquitin as an independent predictor of severe sperm damage and ICSI outcomes: evidence for a redox-proteostasis axis in male infertility†.Biology of reproduction · 2026Article
- The Influence of L-Serine on Sperm Quality, Malondialdehyde, and Antioxidant Enzyme Activity After Cryopreservation in Bull Semen.Animals : an open access journal from MDPI · 2026Article
- Combined Metabolomic and Transcriptomic Analysis Identifies Metabolic Signatures and Networks Associated with Semen Quality in Geese.Animals : an open access journal from MDPI · 2026Article
- Integration of Proteomics and Phenomics to Reveal Molecular Differences in High and Low Semen Quality in Donkeys.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Astaxanthin and Male Reproductive Health: Mechanisms, Experimental Evidence, and Clinical Perspectives.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Association between body mass index and semen quality in infertile men: a cross-sectional study of 28 167 patients.Asian journal of andrology · 2026Article
- Prenatal road traffic noise impairs early testicular development in Sprague-Dawley offspring: pharmacological rescue by melatonin and edaravone; developmental preservation by environmental enrichment.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The Therapeutic Effects ofHealth science reports · 2026Article
- L-Histidine Improves Boar Sperm Quality by Alleviating Oxidative Stress During Preservation at 17 °C.Antioxidants (Basel, Switzerland) · 2026Article
- Impact of Environmental Conditions During IVF Laboratory Handling on Sperm Quality.International journal of molecular sciences · 2026Article
- Liquid Storage and Cryopreservation of Ram Semen: Storage-Associated Damage and the Role of Non-Enzymatic Antioxidants.Veterinary sciences · 2026Review
- Spinal Cord Injury-Related Male Infertility: Oxidative Stress, Inflammation, and Sperm DNA Damage.Journal of clinical medicine · 2026Review
- Optimization of Semen Extender for Mongolian Sheep by Integrating Metabolomics and Sperm Quality Analysis at 17 °C with Antioxidant Supplementation.Animals : an open access journal from MDPI · 2026Article
- Association of Blood Plasma Vascular Endothelial Growth Factor and Testicular Artery Doppler Parameters with Canine Sperm Freezability.Animals : an open access journal from MDPI · 2026Article
105 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress plays a pivotal role in male infertility by impairing sperm function through various molecular mechanisms. This review explores the impact of excessive reactive oxygen species (ROS) on spermatozoa, particularly focusing on lipid peroxidation, DNA fragmentation, and protein oxidation. Lipid peroxidation damages sperm membranes, reducing fluidity and motility. ROS-induced DNA fragmentation compromises genetic integrity, potentially leading to infertility and adverse offspring outcomes. Protein oxidation alters key structural proteins, impairing sperm motility and the ability to fertilize an egg. The primary sources of oxidative stress in sperm include leukocyte activity, mitochondrial dysfunction, and environmental factors such as smoking and pollution. Despite the presence of natural antioxidant defenses, spermatozoa are particularly vulnerable due to limited repair mechanisms. The review highlights the importance of early intervention through antioxidant therapies and lifestyle changes to mitigate the detrimental effects of oxidative stress on male fertility. Further research is essential to enhance therapeutic approaches and improve reproductive outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.