Evidence map›Paper›PMID 39975113›Full record

ArticlebioRxiv : the preprint server for biology2025

Platform-dependent effects of genetic variants on plasma APOL1.

Qingbo S Wang, Jinguo Huang, Leanne Chan, Nicole Haste, Niclas Olsson, Aleksandr Gaun, Fiona McAllister, Deepthi Madhireddy, Amos Baruch, Katie M Cardone and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Qingbo S WangCalico Life Sciences LLC, South San Francisco, CA, USA.
Jinguo HuangCalico Life Sciences LLC, South San Francisco, CA, USA.
Leanne ChanCalico Life Sciences LLC, South San Francisco, CA, USA.
Nicole HasteCalico Life Sciences LLC, South San Francisco, CA, USA.
Niclas OlssonCalico Life Sciences LLC, South San Francisco, CA, USA.
Aleksandr GaunCalico Life Sciences LLC, South San Francisco, CA, USA.
Fiona McAllisterCalico Life Sciences LLC, South San Francisco, CA, USA.
Deepthi MadhireddyCalico Life Sciences LLC, South San Francisco, CA, USA.
Amos BaruchCalico Life Sciences LLC, South San Francisco, CA, USA.
Katie M CardoneDepartment of Genetics and Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Rachit KumarDepartment of Genetics and Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Marylyn RitchieDepartment of Genetics and Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Katalin SusztakRenal Electrolyte and Hypertension Division, Department of Genetics, Penn/CHOP Kidney Innovation Center, Institute for Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA, USA.
Eugene MelamudCalico Life Sciences LLC, South San Francisco, CA, USA.ORCID 0000-0002-5943-6189
Anastasia BaryshnikovaCalico Life Sciences LLC, South San Francisco, CA, USA.

Funding

Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
NIA NIH HHS R01 AG028050NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

Mutations in apolipoprotein L1 (APOL1) are strongly associated with protection against parasitic infections and increased risk of kidney disease in individuals of African ancestry. To better understand the mechanisms underlying APOL1-related pathologies, we examined genetic drivers of circulating APOL1 in individuals of African and European ancestry from four independent cohorts (UK Biobank, AASK, deCODE, and Health ABC) using three proteomic technologies (Olink, SomaLogic, and mass spectrometry). We found that disease-associated

Identifiers

PMID39975113
PMCPMC11838367

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.