ArticlebioRxiv : the preprint server for biology2025
Canalization of circuit assembly by δ-protocadherins in the zebrafish optic tectum.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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4 authors.
Funding
Abstract
Neurons are precisely and reproducibly assembled into complex networks during development. How genes collaborate to guide this assembly remains an enduring mystery. In humans, large numbers of genes have been implicated in neurodevelopmental disorders that are characterized by variable and overlapping phenotypes. The complexity of the brain, the large number of genes involved and the heterogeneity of the disorders makes understanding the relationships between genes, development and neural function challenging. Waddington suggested the concept of canalization to describe the role of genes in shaping developmental trajectories that lead to precise outcomes
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.