Evidence map›Paper›PMID 39975173›Full record

ArticlebioRxiv : the preprint server for biology2025

Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system.

Erich M Schwarz, Jason B Noon, Jeffrey D Chicca, Carli Garceau, Hanchen Li, Igor Antoshechkin, Vladislav Ilík, Barbora Pafčo, Amy M Weeks, E Jane Homan and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Erich M SchwarzDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, 14853, USA.ORCID 0000-0003-3151-4381
Jason B NoonProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0003-4948-7369
Jeffrey D ChiccaProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.ORCID 0009-0009-5153-5914
Carli GarceauProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Hanchen LiProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0003-4146-3450
Igor AntoshechkinDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID 0000-0002-9934-3040
Vladislav IlíkDepartment of Botany and Zoology, Faculty of Science, Masaryk University, Kotlářská 267/2, 611 37 Brno, Czech Republic.ORCID 0000-0002-5246-4523
Barbora PafčoInstitute of Vertebrate Biology, Czech Academy of Sciences, Květná 8, 603 65 Brno, Czech Republic.ORCID 0000-0003-1395-0841
Amy M WeeksDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0003-4700-8256
E Jane HomanioGenetics LLC, 301 South Bedford Street, Ste.1, Madison, WI, 53703, USA.ORCID 0000-0002-2685-8852
Gary R OstroffProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0003-4202-4556
Raffi V AroianProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0002-9741-3834

Funding

Function/optimization of a nematicidal Cry toxin arsenalR01AI056189 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAFFI V AROIAN · 2005 to 2026
$11.0M
A dual-purpose vaccine targeting blood-feeding nematode parasites of sheep and humansR01HD099072 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI AROIAN, RAFFI V · 2019 to 2023
$2.4M
Harnessing Transcriptomics to Identify and Test Novel Hookworm Vaccine TargetsR21AI111173 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI AROIAN, RAFFI V · 2015 to 2016
$462k
NIAID NIH HHS R01 AI056189NIAID NIH HHS R21 AI111173NICHD NIH HHS R01 HD099072
6 · The paper itself

Abstract

Hookworms are intestinal parasitic nematodes that chronically infect ~500 million people, with reinfection common even after clearance by drugs. How infecting hookworms successfully overcome host protective mechanisms is unclear, but it may involve hookworm proteins that digest host tissues, or counteract the host's immune system, or both. To find such proteins in the zoonotic hookworm

Identifiers

PMID39975173
PMCPMC11838427

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.