Evidence map›Paper›PMID 39975338›Full record

ArticlebioRxiv : the preprint server for biology2025

Lipidomic Analysis Reveals Drug-Induced Lipoxins in Glaucoma Treatment.

D J Mathew, S Maurya, J Ho, I Livne-Bar, D Chan, Y Buys, M Sit, G Trope, J G Flanagan, K Gronert and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

D J MathewDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
S MauryaHerbert Wertheim School of Optometry & Vision Science, University of California Berkeley, Berkeley, California, United States.
J HoHerbert Wertheim School of Optometry & Vision Science, University of California Berkeley, Berkeley, California, United States.
I Livne-BarDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
D ChanDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
Y BuysDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
M SitDepartment of Ophthalmology and Vision Science, University of Toronto School of Medicine, Toronto, Canada.
G TropeDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
J G FlanaganHerbert Wertheim School of Optometry & Vision Science, University of California Berkeley, Berkeley, California, United States.
K GronertHerbert Wertheim School of Optometry & Vision Science, University of California Berkeley, Berkeley, California, United States.
J M SivakDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Canada.

Funding

Homeostatic Role and Therapeutic Potential of the Neuroprotective Retinal Lipoxin CircuitR01EY030218 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLANAGAN, JOHN G, GRONERT, KARSTEN · 2020 to 2024
$2.4M
NEI NIH HHS R01 EY030218
6 · The paper itself

Abstract

Synthetic prostaglandin analogues, such as latanoprost, are first-line treatments to reduce intraocular pressure (IOP) in the management of glaucoma, treating millions of patients daily. Glaucoma is a leading cause of blindness, characterized by progressive optic neuropathy, with elevated IOP being the sole modifiable risk factor. Despite this importance, the underlying latanoprost mechanism is still not well defined, being associated with both acute and long term activities, and ocular side effects. Prostaglandins are eicosanoid lipid mediators. Yet, there has not been a comprehensive assessment of small lipid mediators in glaucomatous eyes. Here we performed a lipidomic screen of aqueous humour sampled from glaucoma patients or healthy control eyes. The resulting signature was surprisingly focused on significantly elevated levels of arachidonic acid (AA) and the potent proresolving mediator, lipoxin A

Indexed as

arachidonic acidglaucomaintraocular pressurelatanoprostlipoxinprostaglandin

Identifiers

PMID39975338
PMCPMC11838192

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.