Evidence map›Paper›PMID 39975901›Full record

ArticleResearch square2025

Identification of Hub Genes Involved in Early-onset Schizophrenia: From Genetic Susceptibility to Predicted Regulated Gene Expression.

Yawen Jen, Sung-Liang Yu, Po-Chang Hsiao, Po-Hsiu Kuo, Chih-Min Liu, Chen-Chung Liu, Tzung-Jeng Hwang, Ming H Hsieh, Yi-Ling Chien, Yi-Ting Lin and 10 more

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Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Yawen JenCenter for Neuropsychiatric Research, National Health Research Institutes.
Sung-Liang YuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University.
Po-Chang HsiaoInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University.
Po-Hsiu KuoInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University.
Chih-Min LiuNational Taiwan University Hospital.
Chen-Chung LiuNational Taiwan University Hospital.
Tzung-Jeng HwangNational Taiwan University Hospital.
Ming H HsiehNational Taiwan University Hospital.
Yi-Ling ChienNational Taiwan University Hospital.
Yi-Ting LinNational Taiwan University Hospital.
Hailiang HuangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard.
Yen-Chen Anne FengInstitute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University.
Chuhsing K HsiaoInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University.
Yen-Feng LinCenter for Neuropsychiatric Research, National Health Research Institutes.
Stephen V FaraoneDepartments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, and Public Health and Preventive Medicine, SUNY Upstate Medical University.
Benjamin NealeStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard.
Stephen J GlattDepartments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, and Public Health and Preventive Medicine, SUNY Upstate Medical University.
Ming T TsuangCenter for Behavioral Genomics, Department of Psychiatry, University of California San Diego.
Hai-Gwo HwuNational Taiwan University Hospital.
Wei J ChenCenter for Neuropsychiatric Research, National Health Research Institutes.

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2004 to 2005
$111.5M
NHGRI NIH HHS U54 HG003067NIMH NIH HHS R01 MH085521NIMH NIH HHS R01 MH085560
6 · The paper itself

Abstract

backgroundDespite a high heritability of schizophrenia (SZ), only limited variance was attributed to gene loci or the polygenic risk score in genome-wide association studies (GWAS). Early-onset SZ, a more homogeneous SZ subtype, may aid in bridging the genotype-phenotype gap and the identification of its hub genes is critical for early intervention in clinical practice. We aimed to examine the gene expression risk score (GeRS) in patients from both multiplex and simplex families to identify hub genes for early-onset SZ, and perform enrichment analysis to understand the biological functions of the hub genes.

methodsBased on the GWAS genotype data from patients with SZ in multiplex families (223 early-onset and 372 late-onset) and those from simplex families (matched for sex and onset age), GeRSs for SZ (SZ-GeRSs) were estimated using the SNP-expression prediction model derived from existing brain tissues of patients with psychiatric disorders. Module-based SZ-GeRS was summed over genes from empirically derived gene clusters, network analysis was conducted to identify hub genes, and enrichment analysis was used for functional mapping.

resultsAmong the 13 modules from existing coexpression analyses of

conclusionsGeRS for SZ helps identify six hub genes for early-onset schizophrenia, and the enrichment analysis sheds light on their possible roles in the pathophysiology. These findings will enhance the understanding of SZ etiology and may contribute to early screening and personalized prevention efforts.

Indexed as

Coexpression analysesEarly onsetGene expression risk scoresNetwork analysisPolygenic risk scoreSchizophrenia

Identifiers

PMID39975901
PMCPMC11838744

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.