Evidence map›Paper›PMID 39976226›Full record

ArticleeLife2025

Impact of liver-specific survival motor neuron (SMN) depletion on central nervous system and peripheral tissue pathology.

Monique Marylin Alves de Almeida, Yves De Repentigny, Sabrina Gagnon, Emma R Sutton, Rashmi Kothary

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monique Marylin Alves de AlmeidaRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID https://orcid.org/0000-0002-8594-1410
Yves De RepentignyRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Sabrina GagnonRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Emma R SuttonRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Rashmi KotharyRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID https://orcid.org/0000-0002-9239-7310

Funding

CIHR PJT-186300Muscular Dystrophy Association 10.55762/pc.gr.157042University of Ottawa Brain and Mind Institute TRIMS Award
6 · The paper itself

Abstract

Spinal muscular atrophy (SMA) is caused by mutations in the Survival Motor Neuron 1 (

Indexed as

Central Nervous SystemLiverMotor NeuronsMuscular Atrophy, SpinalSurvival of Motor Neuron 1 ProteinAnimalsDisease Models, AnimalMiceMice, KnockoutMice, TransgenicSmn1 protein, mouseSurvival of Motor Neuron 1 ProteingeneticsgenomicsmetabolismmouseMouseneuromuscular diseaseneurosciencepancreas

Identifiers

PMID39976226
PMCPMC11841985

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.