Evidence map›Paper›PMID 39976440›Full record

ArticleInfection and immunity2025

Paige E Allen, Haley E Adcox, Thomas E Siff, Sarika Gupta, Jason R Hunt, Jason A Carlyon

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Transformation and allelic exchange inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Pathogens (Basel, Switzerland) · 2026
    Article
  5. Identification of candidate nucleomodulins in ESKAPE bacteria -Frontiers in cellular and infection microbiology · 2026
    Article
  6. Review
  7. Pathogens (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paige E AllenDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, USA.ORCID 0000-0002-0299-7380
Haley E AdcoxDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, USA.
Thomas E SiffDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, USA.ORCID 0000-0001-6000-6285
Sarika GuptaDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, USA.
Jason R HuntDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, USA.
Jason A CarlyonDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, USA.ORCID 0000-0003-2778-5066

Funding

Orientia tsutsugamushi Ank-host interactions in scrub typhus pathogenesisR01AI167857 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI Jason A Carlyon · 2022 to 2026
$2.9M
VCU NIGMS Mentoring supplementT32GM144294 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI David Delmar Limbrick · 2022 to 2026
$1.3M
Multifunctional roles of an Orientia tsutsugamushi nucleomodulinF32AI174656 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI Paige Allen · 2023 to 2026
$224k
NIAID NIH HHS F32 AI174656NIAID NIH HHS R01 AI167857NIGMS NIH HHS T32 GM144294
6 · The paper itself

Abstract

Cullin-1 (Cul1), a cullin-RING ubiquitin ligase component, represses c-MYC activity in the nucleus.

Indexed as

ApoptosisCell NucleusCullin ProteinsOrientia tsutsugamushiProto-Oncogene Proteins c-mycScrub TyphusAnimalsBacterial ProteinsHost-Pathogen InteractionsHumansBacterial ProteinsCullin 1Cullin ProteinsProto-Oncogene Proteins c-mycAnkankyrin repeatapoptosisc-MYCcullin-1obligate intracellular bacteriumOrientia tsutsugamushiRickettsiaSCFscrub typhus

Identifiers

PMID39976440
PMCPMC11895443

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.