Evidence map›Paper›PMID 39976511›Full record

ArticleEpigenetics2025

Poly-epigenetic scores for cardiometabolic risk factors interact with demographic factors and health behaviors in older US Adults.

Lisha Lin, Wei Zhao, Zheng Li, Scott M Ratliff, Yi Zhe Wang, Colter Mitchell, Jessica D Faul, Sharon L R Kardia, Kira S Birditt, Jennifer A Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lisha LinDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-6759-9906
Wei ZhaoSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Zheng LiDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Scott M RatliffDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Yi Zhe WangDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Colter MitchellSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Kira S BirdittSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Funding

Health and Retirement Study: Yrs 35-40U01AG009740 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1990 to 2025
$96.8M
Biological Aging Across the Life Course: Harmonizing Cohort Biospecimen ArchivesR01AG071071 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 to 2025
$1.2M
NIAAA NIH HHS R01 AA026687NIA NIH HHS R01 AG060110NIA NIH HHS R01 AG071071NIA NIH HHS U01 AG009740
6 · The paper itself

Abstract

Poly-epigenetic scores (PEGS) are surrogate measures that help capture individual-level risk. Understanding how the associations between PEGS and cardiometabolic risk factors vary by demographics and health behaviors is crucial for lowering the burden of cardiometabolic diseases. We used results from established epigenome-wide association studies to construct trait-specific PEGS from whole blood DNA methylation for systolic and diastolic blood pressure (SBP, DBP), body mass index (BMI), C-reactive protein (CRP), high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglycerides (TG), and fasting glucose. Overall and race-stratified associations between PEGS and corresponding traits were examined in adults >50 years from the Health and Retirement Study (

Indexed as

Cardiometabolic Risk FactorsDNA MethylationEpigenesis, GeneticHealth BehaviorAgedAged, 80 and overBlood PressureBody Mass IndexCholesterol, HDLC-Reactive ProteinFemaleHumansMaleMiddle AgedRisk FactorsTriglyceridesCholesterol, HDLC-Reactive ProteinTriglyceridesblood lipidsblood pressurebody mass indexcardiometabolic risk factorsDNA methylationglucoseinflammationPoly-epigenetic score

Identifiers

PMID39976511
PMCPMC11844928

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.