Evidence map›Paper›PMID 39976627›Full record

ArticleActa diabetologica2025

Correlation between Sirtuin 1 downregulation and reduced vitamin D receptor expression in patients with diabetic neuropathy.

Andrea Latini, Giada De Benedittis, Chiara Morgante, Beatrice Gasperini, Ilenia D'Ippolito, Davide Lauro, Giuseppe Novelli, Cinzia Ciccacci, Vincenza Spallone, Paola Borgiani

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Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Andrea LatiniDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Giada De BenedittisDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Chiara MorganteDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Beatrice GasperiniDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Ilenia D'IppolitoDepartment of Systems Medicine, Endocrinology Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Davide LauroDepartment of Systems Medicine, Endocrinology Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Giuseppe NovelliDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Cinzia CiccacciUniCamillus, Saint Camillus International University of Health Sciences, 00131, Rome, Italy.
Vincenza SpalloneDepartment of Systems Medicine, Endocrinology Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Paola BorgianiDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy. borgiani@med.uniroma2.it.ORCID http://orcid.org/0000-0003-0859-4328

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe aimed to analyse Sirtuin 1 (SIRT1) and Vitamin D receptor (VDR) expression levels in the peripheral blood of patients with type 2 diabetes (T2D), characterized for the presence of diabetic neuropathy (DN), and to evaluate possible genetic factors that could influence the VDR expression levels.

methodsFifty-one participants with T2D, who underwent neurological assessment for DN were recruited. We quantified the mRNA levels of SIRT1 and VDR in peripheral blood mononuclear cells. Moreover, we analysed the methylation status and the rs2228570 genetic variant of VDR promoter.

resultsPatients with DN (n = 32) showed lower expression of SIRT1 (p

conclusionIn patients with DN, both SIRT1 and VDR expression levels are reduced and interrelated. Low VDR expression levels could negatively affect SIRT1 transcription, thus influencing all the most pathogenetic pathways of DN regulated by this protein.

Indexed as

Diabetes Mellitus, Type 2Diabetic NeuropathiesReceptors, CalcitriolSirtuin 1AgedDown-RegulationFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticReceptors, CalcitriolSIRT1 protein, humanSirtuin 1VDR protein, humanDiabetic neuropathySIRT1Vitamin D receptor

Identifiers

PMID39976627
PMCPMC12433372

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.