Evidence map›Paper›PMID 39976713›Full record

ReviewZeitschrift fur Rheumatologie2025

["Paradoxical fractures": pathological fractures under anti-osteoporotic and antirheumatic treatment].

Edgar Wiebe, Paula Hoff, Frank Buttgereit

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Zeitschrift fur Rheumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Methotrexate osteopathy-a critical review].Zeitschrift fur Rheumatologie · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Edgar WiebeMed. Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie und Interdisziplinäres Zentrum für Osteologie, Charité Universitätsmedizin Berlin (Campus Mitte), Charitéplatz 1, 10117, Berlin, Deutschland. edgar.wiebe@charite.de.
Paula HoffMed. Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie und Interdisziplinäres Zentrum für Osteologie, Charité Universitätsmedizin Berlin (Campus Mitte), Charitéplatz 1, 10117, Berlin, Deutschland.
Frank ButtgereitMed. Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie und Interdisziplinäres Zentrum für Osteologie, Charité Universitätsmedizin Berlin (Campus Mitte), Charitéplatz 1, 10117, Berlin, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathological fractures under anti-osteoporotic and antirheumatic treatment are very rare events. Nevertheless, atypical femoral fractures occur during antiresorptive treatment with bisphosphonates or denosumab, the latter especially in patients previously treated with bisphosphonates. Treatment with teriparatide can be helpful. While glucocorticoids have a well-known influence on the development of osteoporosis and thus also fractures, the probably unproblematic use in the low-dose range has so far found little acceptance. Methotrexate-induced osteopathy is also a rare phenomenon but is now well accepted and known. There are several approved medications for the treatment of glucocorticoid-induced osteoporosis and for methotrexate-induced osteopathy, discontinuation of methotrexate is particularly essential.

Indexed as

Antirheumatic AgentsFractures, SpontaneousOsteoporosisOsteoporotic FracturesBone Density Conservation AgentsDenosumabDiphosphonatesEvidence-Based MedicineGlucocorticoidsHumansMethotrexateTeriparatideTreatment OutcomeAntirheumatic AgentsBone Density Conservation AgentsDenosumabDiphosphonatesGlucocorticoidsMethotrexateTeriparatideBisphosphonateDenosumabGlucocorticoid-induced osteoporosisMethotrexate-induced osteopathyPathological fractures

Identifiers

PMID39976713

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.