Evidence map›Paper›PMID 39976797›Full record

ArticleMarine biotechnology (New York, N.Y.)2025

Flow Velocity Modulates Growth, Oxidative Stress, and Transcriptomic Responses in Spotted Sea Bass (Lateolabrax maculatus).

Shuo Li, Yuyan Liu, Qian Wang, Zhiwen Zhu, Weijing Li, Chen Li, Fan Fei, Baoliang Liu, Changwei Shao

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Transcriptomic Analysis ofAnimals : an open access journal from MDPI · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Shuo Li *State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo, 315211, People's Republic of China.
Yuyan Liu *State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, Shandong, China.
Qian WangLaboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, 266237, Shandong, China.
Zhiwen ZhuState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, Shandong, China.
Weijing LiState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, Shandong, China.
Chen LiState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, Shandong, China.
Fan FeiState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, Shandong, China.
Baoliang LiuLaboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, 266237, Shandong, China. liubl@ysfri.ac.cn.
Changwei ShaoLaboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, 266237, Shandong, China. shaocw@ysfri.ac.cn.

Funding

Marine S&T Fund of Shandong Province for Qingdao Marine Science and Technology Center 2022QNLM030001the AoShan Talents Cultivation Program Supported by Qingdao National Laboratory for Marine Science and Technology 2017ASTCP-ES06the Key R&D Program of Hebei Province, China 21326307Dthe Key Research and Development Project of Shandong Province 2022LZGC016the National Key R&D Program of China 2022YFD2400100the National Science and Technology Innovation 2030-Major Program 2022ZD0401803the National Ten-Thousands Talents Special Support Program to C.S, the Central Public-interest Scientific Institution Basal Research Fund, CAFS grant number 2023TD19the Science and Technology Development Plan Project of Weifang City 2023ZJ1056the Taishan Scholars Program to C.S NO. tstp20221149
6 · The paper itself

Abstract

Flow velocity is a critical environmental factor influencing the growth, energy metabolism, and physiological health of aquaculture species. This study investigated the physiological and molecular responses of spotted sea bass (Lateolabrax maculatus) under experimental conditions simulating flow velocities typical of land-based recirculating aquaculture systems (RAS) and deep-sea cage systems. High flow velocities (HFV, 0.35-0.65 body lengths per second [BL/s]) enhanced growth performance compared to low flow velocity (LFV, 2.28-2.85 BL/s) conditions. Histological analysis revealed reduced hepatic lipid accumulation under HFV, while LFV promoted lipid storage. Serum analyses showed elevated antioxidant enzyme activity in the LFV group but higher oxidative stress markers in the HFV group. Transcriptomic profiling identified foxo3 as a key regulatory hub orchestrating metabolic and oxidative stress adaptations. Genes associated with oxidative damage repair, lipid catabolism, and glucose metabolism were significantly enriched under hydrodynamic stress. Enrichment of the FoxO signaling pathway highlighted its central role in mediating oxidative stress mitigation and energy mobilization. These findings demonstrate the dual effects of flow velocity, where higher velocities promote growth and metabolic activity at the cost of oxidative stress, and lower velocities conserve energy while maintaining oxidative stability. Tailored flow velocity conditions can optimize fish welfare and productivity across aquaculture systems. Future studies should investigate the systemic effects of hydrodynamic stress using multi-omics approaches to advance sustainable aquaculture practices.

Indexed as

BassOxidative StressTranscriptomeAnimalsAquacultureFish ProteinsForkhead Box Protein O3Lipid MetabolismLiverFish ProteinsForkhead Box Protein O3Flow velocityLipid metabolismOxidative stressSpotted sea bassTranscriptomics

Identifiers

PMID39976797

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.