Evidence map›Paper›PMID 39976835›Full record

ReviewCurrent oncology reports2025

Advancements in the Diagnosis, Treatment, and Risk Stratification of Non-Muscle Invasive Bladder Cancer.

Shayan Smani, Julien DuBois, Kai Zhao, Ryan Sutherland, Syed N Rahman, Peter Humphrey, David Hesse, Wei Shen Tan, Darryl Martin, Soum D Lokeshwar and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shayan SmaniDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA.
Julien DuBoisDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA.
Kai ZhaoDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA.
Ryan SutherlandDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA.
Syed N RahmanDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA.
Peter HumphreyDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
David HesseDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA.
Wei Shen TanDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA.
Darryl MartinDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA.
Soum D LokeshwarDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA.
Fady GhaliDepartment of Urology, Yale University School of Medicine, 789 Howard Avenue FMP 300, New Haven, CT, 06520, USA. fed.ghali@yale.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review examines the evolving landscape of non-muscle invasive bladder cancer (NMIBC) management, focusing on risk stratification, novel therapeutic strategies, and the integration of biomarkers into clinical care. RECENT

findingsEmerging genomic markers such as FGFR3 and TERT promoter mutations show promise for diagnosis and personalized treatment. Advances in immunotherapy, including the use of pembrolizumab and nadofaragene firadenovec, offer options for BCG-unresponsive NMIBC, though challenges like cost and adverse effects remain. Current guidelines emphasize stratified care based on risk, balancing treatment intensity with recurrence and progression risks. While transurethral resection with intravesical therapy remains the standard for most NMIBC, early radical cystectomy is pivotal for select high-risk cases. Future directions highlight the need for biomarker-driven models to refine treatment paradigms, reduce overtreatment, and improve long-term outcomes. Continued clinical trials are essential to validate these approaches and address unmet needs in NMIBC care.

Indexed as

Urinary Bladder NeoplasmsAntibodies, Monoclonal, HumanizedBiomarkers, TumorCystectomyHumansImmunotherapyNeoplasm InvasivenessNon-Muscle Invasive Bladder NeoplasmsRisk AssessmentAntibodies, Monoclonal, HumanizedBiomarkers, TumorpembrolizumabBladder neoplasmsImmunotherapyNon-muscle invasive bladder cancerRadical cystectomyRisk stratification

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.