SynthesisAmerican journal of hypertension2025
Elevated Blood Pressure and Cardiac Mechanics in Children and Adolescents: A Systematic Review and Meta-Analysis.
Synthesis in American journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Hypertension in Children: Narrative Review of Epidemiology, Outcome and Target Organ Damage.Children (Basel, Switzerland) · 2026Review
- Circulating miR-16 as an Early Biomarker of Subclinical Myocardial Strain Impairment in Pediatric Primary Hypertension.International journal of molecular sciences · 2026Article
- Longitudinal Insights Into Pediatric Hypertension, Cardiac Consequences, and Physical Activity.Current hypertension reports · 2026Review
- Turner syndrome across the lifespan: a 25-year single-center experience from neonatal diagnosis to adult outcomes.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionEvidence on left ventricular (LV) mechanics, assessed by speckle tracking echocardiography (STE), in children and adolescents with elevated blood pressure (BP)/hypertension is scanty.
aimThe aim of the present meta-analysis was to provide an updated information on LV systolic function phenotyped by global longitudinal strain (GLS) and LV ejection fraction (LVEF) in the setting of pediatric hypertension.
methodsSystematic searches were conducted across bibliographic databases (Pub-Med, OVID, EMBASE, and Cochrane Library) to identify eligible studies from inception up to 30 November 2024. Studies reporting data on LV mechanics in pediatric hypertension and controls were included. The statistical difference of the echocardiographic variables of interest between groups such as LVEF and GLS was calculated by standardized mean difference (SMD) with 95% confidence interval (CI) using random-effects models.
resultsEight studies including 719 individuals with elevated BP/hypertension and 1,653 age-matched healthy controls were considered for the analysis. Pooled average LVEF values were 72.4 ± 1.6% in the healthy control group and 72.5 ± 1.8% in the elevated BP/hypertensive group (SMD: 0.08 ± 0.15, CI: -0.21/0.36, P = 0.60); the corresponding values of GLS were -19.6 ± 1.1% and 18.5 ± 0.9% (SMD: -0.96 ± 0.25, CI: -1.46/-0.47, P < 0.0001). A parallel impairment of global circumferential strain emerged from pooled data of three studies (SMD: -0.96 ± 0.25, CI: -1.46/-0.47, P < 0.0001).
conclusionsOur data suggest that LVEF is unable to detect early alterations in systolic function in pediatric hypertension, and the implementation of STE may be highly useful in unmasking systolic dysfunction in this setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.