Evidence map›Paper›PMID 39977612›Full record

ArticleMolecular pharmaceutics2025

Mucin Mimics and Impacts the Function of Polymeric Inhibitors in Stabilizing Drug Supersaturation.

Victus Kordorwu, Steven Castleberry, Steve Lustig, Rebecca L Carrier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Victus KordorwuDepartment of Chemical Engineering, College of Engineering, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0009-0000-9617-4790
Steven CastleberrySmall Molecule Pharmaceutical Sciences, Research and Early Development, Genentech Inc., South San Francisco, California 94080, United States.
Steve LustigDepartment of Chemical Engineering, College of Engineering, Northeastern University, Boston, Massachusetts 02115, United States.
Rebecca L CarrierDepartment of Chemical Engineering, College of Engineering, Northeastern University, Boston, Massachusetts 02115, United States.

Funding

Impact of Lipids on Compound Absorption: Mechanistic Studies and ModelingR01GM098117 · NIGMS · NORTHEASTERN UNIVERSITY · PI CARRIER, REBECCA L · 2012 to 2021
$3.3M
Impact of lipids and food on oral compound absorption: mechanistic studies and modelingR35GM153324 · NIGMS · NORTHEASTERN UNIVERSITY · PI Rebecca L Carrier · 2024 to 2026
$1.3M
NIGMS NIH HHS R01 GM098117NIGMS NIH HHS R35 GM153324
6 · The paper itself

Abstract

Many drugs entering clinical trials today are poorly water-soluble and rely on supersaturating formulations, such as amorphous solid dispersions (ASD) to enhance their bioavailability. The

Indexed as

MucinsPolymersBiological AvailabilityCarvedilolChemical PrecipitationChemistry, PharmaceuticalDrug CompoundingDrug StabilityHypromellose DerivativesNifedipinePolyvinylsSolubilityCarvedilolHypromellose DerivativesMucinsNifedipinePolymersPolyvinylsASDbiorelevant dissolutioncrystallizationintestinal mucusprecipitationsupersaturated solution

Identifiers

PMID39977612
PMCPMC11881134

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.