Evidence map›Paper›PMID 39978049›Full record

ReviewBiomaterials2025

Engineering multifunctional surface topography to regulate multiple biological responses.

Mohammad Asadi Tokmedash, Changheon Kim, Ajay P Chavda, Adrian Li, Jacob Robins, Jouha Min

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Liquid-Responsive Shape-Memory Nanofiber-Reinforced Scaffolds for Cartilage Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  15. Review
  16. Article
  17. Advances in using biomaterials for repairing thin endometrium.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad Asadi TokmedashDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Changheon KimDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Ajay P ChavdaDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Adrian LiDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Jacob RobinsDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Jouha MinDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA; Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: jouhamin@umich.edu.

Funding

Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
Understanding Impact of Controlled 3D Topographical Design on Biological InteractionsR35GM157070 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jouha Min · 2025 to 2026
$749k
NIGMS NIH HHS R35 GM157070NIGMS NIH HHS T32 GM145304
6 · The paper itself

Abstract

Surface topography or curvature plays a crucial role in regulating cell behavior, influencing processes such as adhesion, proliferation, and gene expression. Recent advancements in nano- and micro-fabrication techniques have enabled the development of biomimetic systems that mimic native extracellular matrix (ECM) structures, providing new insights into cell-adhesion mechanisms, mechanotransduction, and cell-environment interactions. This review examines the diverse applications of engineered topographies across multiple domains, including antibacterial surfaces, immunomodulatory devices, tissue engineering scaffolds, and cancer therapies. It highlights how nanoscale features like nanopillars and nanospikes exhibit bactericidal properties, while many microscale patterns can direct stem cell differentiation and modulate immune cell responses. Furthermore, we discuss the interdisciplinary use of topography for combined applications, such as the simultaneous regulation of immune and tissue cells in 2D and 3D environments. Despite significant advances, key knowledge gaps remain, particularly regarding the effects of topographical cues on multicellular interactions and dynamic 3D contexts. This review summarizes current fabrication methods, explores specific and interdisciplinary applications, and proposes future research directions to enhance the design and utility of topographically patterned biomaterials in clinical and experimental settings.

Indexed as

Biocompatible MaterialsBiomimetic MaterialsCellsMicrotechnologyNanotechnologyNanostructuresSurface PropertiesBiocompatible MaterialsBiofilm controlBiomaterialsCancer treatmentImmunomodulationSurface topographyTissue engineering

Identifiers

PMID39978049
PMCPMC11893264

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.