Evidence map›Paper›PMID 39978055›Full record

ReviewCurrent opinion in chemical biology2025

Lipid probes to study ion channels.

Helene Jahn, Show-Ling Shyng, Carsten Schultz

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Helene JahnDepartment of Chemical Physiology and Biochemistry, School of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA; Department of Molecular Microbiology and Immunology, School of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA.
Show-Ling ShyngDepartment of Chemical Physiology and Biochemistry, School of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA. Electronic address: shyngs@ohsu.edu.
Carsten SchultzDepartment of Chemical Physiology and Biochemistry, School of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA. Electronic address: schulcar@ohsu.edu.

Funding

Structural Basis of KATP Channel GatingR01DK066485 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHYNG, SHOW-LING · 2006 to 2024
$5.8M
Chemical biology tools for studying growth factor receptor internalizationR01GM127631 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHULTZ, CARSTEN · 2018 to 2024
$2.4M
Correlating structure and function in KATP channel isoformsR01GM145784 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHYNG, SHOW-LING · 2022 to 2025
$1.5M
Multifunctionalized lipid derivativesR35GM158174 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Carsten Schultz · 2025 to 2026
$839k
SecreTrap - a tool to measure peptide hormone secretion at the single cell levelR21GM141570 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHULTZ, CARSTEN · 2021 to 2022
$424k
NIDDK NIH HHS R01 DK066485NIGMS NIH HHS R01 GM127631NIGMS NIH HHS R01 GM145784NIGMS NIH HHS R21 GM141570NIGMS NIH HHS R35 GM158174
6 · The paper itself

Abstract

Lipids can have specific interaction partners and act as small molecule regulators of proteins, especially for transmembrane proteins. Transmembrane proteins, such as ion channels, can be influenced by lipids in four ways; lipids can be direct ligands, localize effector proteins or domains, affect protein-protein interaction, or change the biophysical properties of the surrounding membrane. In this article, we will give examples of how lipids directly interact with ion channels and address the complex aspect of indirect regulation via lipids of the surrounding membrane bilayer. In addition, we discuss current and propose future molecular tools and experiments elucidating the many roles lipids play in ion channel function.

Indexed as

Ion ChannelsLipidsMolecular ProbesAnimalsHumansLipid BilayersIon ChannelsLipid BilayersLipidsMolecular ProbesCaged lipidsInteractomeLigandPhoto-crosslinkable lipidsProtein structure

Identifiers

PMID39978055
PMCPMC13182285

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.