Evidence map›Paper›PMID 39979537›Full record

ArticleAnnals of intensive care2025

[

Bram van Leer, Jelle L G Haitsma Mulier, Cornelis P van Stee, Kiki M Demenaga, Riemer H J A Slart, Matijs van Meurs, Andor W J M Glaudemans, Maarten W N Nijsten, Lennie P G Derde, Janesh Pillay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Diagnostic value of [European journal of nuclear medicine and molecular imaging · 2026
    Pooled it
  2. Article
  3. Determinants of diagnostic yield and scan quality of [Critical care (London, England) · 2026
    Article
  4. [Frontiers in medicine · 2026
    Article
  5. Article
  6. A scoping review on potential of novel developments in fever of unknown origin and inflammation of unknown origin: long-axial-field-of-view positron emission tomography/computed tomography and novel radiotracers.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bram van LeerDepartment of Critical Care, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. b.van.leer@umcg.nl.ORCID http://orcid.org/0000-0002-6597-205X
Jelle L G Haitsma MulierIntensive Care Center, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Cornelis P van SteeDepartment of Critical Care, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Kiki M DemenagaDepartment of Critical Care, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Riemer H J A SlartDepartment of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Matijs van MeursDepartment of Critical Care, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Andor W J M GlaudemansDepartment of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Maarten W N NijstenDepartment of Critical Care, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Lennie P G DerdeIntensive Care Center, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Janesh PillayDepartment of Critical Care, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Funding

ZonMw 09032212110044
6 · The paper itself

Abstract

purposeSome ICU patients remain critically ill despite reversal of the original admission diagnosis, driven by a cascade of events resulting in new and persistent organ failure. Secondary infections and systemic inflammation are important components of this cascade and may be visualised using [

methodsWe included patients admitted to the ICU between 2017 and 2024, in whom a [

resultsForty-seven patients with persistent critical illness were included from two university medical centres. The median interval between admission and PET/CT was 21 days (IQR 14-28). In 43 patients (91%) a potential infectious or inflammatory focus was detected, of which 34 (72%) were previously unknown. The [

conclusion[

Indexed as

[18F]FDG PET/CTICUImagingPersistent critical illnessSystemic inflammation

Identifiers

PMID39979537
PMCPMC11842666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.