ArticleEye (London, England)2025
Mendelian randomization analysis revealed a gut microbiota-eye axis in acute anterior uveitis.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association between Guillain-Barré syndrome and 7 autoimmune diseases: a mendelian randomization study.BMC neurology · 2026Article
- Sex-specific associations between gut microbiota and myopia in adolescents: a clinical predictive modeling study.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundObservational studies suggest that gut microbiome (GM) may contribute to acute anterior uveitis (AAU) development, but causality remains unclear. This study was conducted to test whether specific GM taxa were causally associated with AAU.
methodsThe GM data were obtained from the DMP, which included 7738 individuals' faecal samples and an analysis of host genotype-taxa abundance associations. The AAU data were derived from the FinnGen Consortium (8624 cases and 473,095 controls). We primarily employed the inverse-variance weighted method, complemented by supplementary sensitivity analyses.
resultsHigher abundance of Lachnospiraceae noname (OR = 0.86, 95% CI 0.81-0.91, P = 5.7 × 10
conclusionThis study suggests that specific GM is causally associated with AAU risk, warranting more mechanistic validation and clinical trials.
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