Evidence map›Paper›PMID 39979755›Full record

Observational studyInternal and emergency medicine2025

Demographic and regional trends in systemic and cardiovascular amyloidosis-related mortality among older adults in the United States from 1999 to 2020.

Jasninder Singh Dhaliwal, Fatima Hussain, Hamza Ahmed, Abeer T M A Khan, Abdullah Aslam Khan, Maha Asghar Memon, Maha Arshad, Sayed Maisum Mehdi, Anum Touseef Hussain, Ayesha Ali Rind and 4 more

Abstract readObservational Study
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In one paragraph

Observational study in Internal and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jasninder Singh DhaliwalInternal Medicine Resident, University of California, Riverside, California, USA.
Fatima HussainDepartment of Medicine, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan, P.O. Box 74200. saimafatima.hussain@gmail.com.ORCID 0009-0006-7905-4133
Hamza AhmedDepartment of Medicine, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan, P.O. Box 74200.
Abeer T M A KhanDepartment of Medicine, Rawal Institute of Health Sciences, Islamabad, Pakistan.
Abdullah Aslam KhanDepartment of Medicine, Rawal Institute of Health Sciences, Islamabad, Pakistan.
Maha Asghar MemonDepartment of Medicine, Ziauddin University, Karachi, Pakistan.
Maha ArshadDepartment of Medicine, Ziauddin University, Karachi, Pakistan.
Sayed Maisum MehdiDepartment of Medicine, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan, P.O. Box 74200.
Anum Touseef HussainDepartment of Medicine, CMH Lahore Medical and Dental College, Lahore, Pakistan.
Ayesha Ali RindDepartment of Medicine, Ziauddin University, Karachi, Pakistan.
Syeda Umbreen MunirDepartment of Medicine, Karachi Medical and Dental College, Karachi, Pakistan.
Bilal AliDepartment of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Kashaf NadeemDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Ahmed Mustafa RashidDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite therapy advancements, amyloidosis mortality rates for older adults (aged ≥ 65) are rising. This study analyzes trends in amyloidosis-related mortality among older adults in the U.S. We conducted a cross-sectional analysis of death certificates from the CDC WONDER database for amyloidosis-related deaths from 1999 to 2020. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change (APC) were calculated by age, race/ethnicity, urban-rural classification, and region. From 1999 to 2020, AAMR for amyloidosis in older adults (aged ≥ 65) in the U.S. increased from 2.7 to 5.6. Men consistently had higher AAMRs than women (men: 3.7 vs. women: 2.2 in 1999; men: 8.5 vs. women: 3.5 in 2020). In 2020, Non-Hispanic Blacks had the highest AAMR at 11.8, with an APC of 19.8 (95% CI 10.5-25.5). Regional differences were notable, with AAMRs highest in the Northeast (6.9) and lowest in the South (4.2). Large metropolitan areas had a higher AAMR (6.3) than non-metropolitan areas (4.6). Cardiac amyloidosis accounted for 68.8% of deaths, with AAMR rising from 1.7 to 4.2. There has been a significant increase in AAMRs for amyloidosis in the U.S. from 1999 to 2020, particularly among males, Non-Hispanic Blacks, and those in large metropolitan and Northeast areas. These findings stress the need for enhanced prevention and treatment strategies for older adults.

Indexed as

AmyloidosisCardiovascular DiseasesAgedAged, 80 and overCross-Sectional StudiesDemographyFemaleHumansMaleMortalityUnited StatesAmyloidosisCardiomyopathiesMortalityOlder adultsTrends

Identifiers

PMID39979755

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.