SynthesisBMC medical research methodology2025
A systematic review of mediation analysis frameworks in studies examining the determinants of cardiometabolic outcomes in people living with HIV.
Synthesis in BMC medical research methodology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Post-marketing safety concerns with dolutegravir: a pharmacovigilance study based on the FDA adverse event reporting system database.Frontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionMediation analysis provides a more flexible mechanistic view of the causal relationship between HIV-related factors and cardiometabolic diseases. However, there is limited evidence on how mediation analysis is implemented in this specific research area. We aimed to describe the frameworks used in mediation analysis and examine how these analyses are conducted and reported in studies focusing on cardiometabolic outcomes among people living with HIV (PLWH).
methodsFollowing the PRISMA 2020 Guidelines, we comprehensively searched Medline, CINAHL, Africa-Wide Information and SCOPUS to identify observational studies that employed mediation analysis before October 2023. Two reviewers independently screened studies for eligibility. One reviewer performed data extraction, and two others reviewed the extracted information.
resultsNine studies met the inclusion criteria, predominantly focusing on the mediation effects of weight and obesity-related factors on the relationship between HIV serostatus, ART, and cardiometabolic outcomes. The review revealed a diverse application of both traditional and causal mediation frameworks. However, inconsistencies and gaps in reporting were noted, particularly in handling missing data, detailing identifiability assumptions, and the use of sensitivity analyses.
conclusionWhile some studies of cardiometabolic risks among PLWH have embraced causal mediation frameworks, their overall application remains limited. In addition, we identified notable inconsistencies and gaps in reporting practices. To advance the field, researchers should not only integrate more rigorous causal mediation methods but also closely follow established reporting guidelines, such as the AGReMA Statement, to ensure greater transparency, reliability, and impact of future research.
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Registered trials
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