Evidence map›Paper›PMID 39981072›Full record

ArticleOpen forum infectious diseases2025

Diminished

Aparajita Saha, Jaclyn N Escudero, Troy Layouni, Jerphason Mecha, Elizabeth Maleche-Obimbo, Daniel Matemo, John Kinuthia, Grace John-Stewart, Barbra A Richardson, Sylvia M LaCourse and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Physiological stage-dependent effects ofFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aparajita SahaDepartment of Medicine, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-5014-6687
Jaclyn N EscuderoDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-3513-774X
Troy LayouniVA Puget Sound Health Care System, Seattle, Washington, USA.
Jerphason MechaCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.ORCID https://orcid.org/0009-0008-6446-0395
Elizabeth Maleche-ObimboDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0001-7871-3367
Daniel MatemoCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.
John KinuthiaDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0001-6571-8927
Grace John-StewartDepartment of Medicine, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-4301-1573
Barbra A RichardsonDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Sylvia M LaCourseDepartment of Medicine, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-9809-5997
Javeed A ShahDepartment of Medicine, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-2997-7988

Funding

Seattle Tuberculosis Research Advancement CenterP30AI168034 · NIAID · UNIVERSITY OF WASHINGTON · PI Rhea N Coler, CHETAN SESHADRI · 2022 to 2026
$6.3M
The effect of HIV exposure and infection on immunity to TB in childrenR01AI142647 · NIAID · UNIVERSITY OF WASHINGTON · PI DAY, CHERYL LIANE, JOHN-STEWART, GRACE C. · 2019 to 2023
$4.1M
TOLLIP Deficiency, Immune Dysregulation, and Tuberculosis SusceptibilityR01AI136921 · NIAID · UNIVERSITY OF WASHINGTON · PI SHAH, JAVEED ALI · 2018 to 2022
$2.5M
Impact of maternal HIV on Mycobacterium tuberculosis infection among peripartum women and their infantsK23AI120793 · NIAID · UNIVERSITY OF WASHINGTON · PI LACOURSE, SYLVIA · 2016 to 2020
$910k
Dynamics of tuberculosis immune response in peripartum HIV-infected and HIV-uninfected womenR21HD098746 · NICHD · UNIVERSITY OF WASHINGTON · PI LACOURSE, SYLVIA, SHAH, JAVEED ALI · 2019 to 2020
$428k
NIAID NIH HHS K23 AI120793NIAID NIH HHS P30 AI168034NIAID NIH HHS R01 AI136921NIAID NIH HHS R01 AI142647NICHD NIH HHS R21 HD098746
6 · The paper itself

Abstract

Background: Pregnancy increases Methods: We measured adaptive immune responses from 33 participants (HIV+ 21, HIV- 12) with positive interferon-gamma release assay during pregnancy (20-34 weeks' gestation), 6 weeks, and 12 months postpartum by intracellular cytokine staining. We measured overall responses using COMPASS and made comparisons by nonparametric analysis of variance. Result: We observed diminished Mtb-specific CD4+ T-cell responses in WLHIV during pregnancy versus 12 months postpartum (COMPASS median functional score [FS] .009 vs 0.12, Conclusions: Pregnant WLHIV, especially those on IPT, showed reduced Mtb-specific CD4+ T-cell responses. Understanding the impact of pregnancy on Mtb-specific T-cell responses may improve diagnostic approaches.

Indexed as

HIVisoniazid preventative therapyLTBIpregnancyT cellstuberculosis

Identifiers

PMID39981072
PMCPMC11842132

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.