Evidence mapPaperPMID 39981080Full record

SynthesisFrontiers in medicine2025

Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis.

Donna Pratiwi, Miko Sidartha, Elvan Wiyarta, I Wayan Agustinus Harimawan, Ni Made Dwi Asti Lestari, Bonglee Kim, Nurpudji Astuti Taslim, Trina Ekawati Tallei, Fahrul Nurkolis, Rony Abdi Syahputra

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Hepatogenomics of MAFLD in Asian Population: Genetic Polymorphisms and Pathway-Based Insights.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  3. Article
  4. The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  5. Review
  6. Exploring the Association ofBiomolecules · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Donna PratiwiDepartment of Clinical Nutrition, Ternate Regional General Hospital, Ternate, Indonesia.
Miko SidarthaDepartment of Internal Medicine, Bhayangkara Police Hospital Ternate, Ternate, Indonesia.
Elvan WiyartaCritical Care Department, University of Indonesia Hospital, Depok, Indonesia.
I Wayan Agustinus HarimawanDepartment of Clinical Nutrition, Prof.dr.I.G.N.G Ngoerah General Hospital, Bali, Indonesia.
Ni Made Dwi Asti LestariDepartment of Clinical Nutrition, Bali Mandara General Hospital, Bali, Indonesia.
Bonglee KimDepartment of Pathology, College of Korean Medicine, Kyung Hee Universitygu, Seoul, Republic of Korea.
Nurpudji Astuti TaslimDepartment of Clinical Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Trina Ekawati TalleiDepartment of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia.
Fahrul NurkolisDepartment of Biological Sciences, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, Indonesia.
Rony Abdi SyahputraDepartment of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This study aims to examine the comparative risk of obesity in the FTO rs9939609 genotype in multiethnic groups in Asia, considering that obesity has become a global disease. Data synthesis: Data searches were carried out in several electronic databases: PubMed, Scopus, Google Scholar, ScienceDirect, ClinicalTrials.gov and NCBI. The search involved a combination of keywords related to genetics and obesity risk. Pooled Odds Ratio (POR) with 95% CI was calculated based on the pooled data. Review Manager (RevMan) 5.4.1 were used to analyze the data. Results: From 18 studies, the results of the dominant genetic model AA vs. TT showed POR 95%Cl = 1.95 (1.36-2.80); Conclusion: From this research, it was found that there was a comparison of the genotype that had a higher risk of obesity, namely the AA genotype in multiethnic groups in Asia. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=546434.

Indexed as

AA genotypeAsiaFTO gene rs9939609multiethnic groupsobesity risk

Identifiers

PMID39981080
PMCPMC11839718

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.