Evidence map›Paper›PMID 39981239›Full record

ArticleFrontiers in immunology2025

Detection of chimeric alpha-defensin transcripts and peptides in mouse Paneth cells.

Steven Timmermans, Charlotte Wallaeys, Somara De Beul, Natalia Garcia-Gonzales, Claude Libert

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Steven TimmermansCenter for Inflammation Research, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.
Charlotte WallaeysCenter for Inflammation Research, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.
Somara De BeulCenter for Inflammation Research, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.
Natalia Garcia-GonzalesCenter for Inflammation Research, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.
Claude LibertCenter for Inflammation Research, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In mammals, Paneth cells, located in the crypts of the small intestine, produceantimicrobial peptides that serve to keep the intestinal microbiome under control. a-Defensins are the primary antimicrobial peptides produced by these cells. Methods: We used 148 publicly available bulk RNA-seq samples on purified PCs, proteomics on enriched purified PC proteins and Results: We identified 28 expressed Conclusion: We show the existence of chimeric

Indexed as

alpha-DefensinsPaneth CellsPeptidesAnimalsAntimicrobial PeptidesMiceRNA, Messengeralpha-DefensinsAntimicrobial PeptidesPeptidesRNA, Messengeralpha-defensinanti-microbial activitieschimeric proteinMus musculusPaneth cell

Identifiers

PMID39981239
PMCPMC11840258

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.