Evidence map›Paper›PMID 39981934›Full record

ArticleInternational journal of oncology2025

Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation.

Yuxin Zheng, Kefeng Wang, Wenli Mao, Guojun Zhang, Xiaomin Han, Hualin Li, Yukun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuxin ZhengDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.
Kefeng WangDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.
Wenli MaoDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.
Guojun ZhangDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.
Xiaomin HanDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.
Hualin LiDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.
Yukun WangDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non‑small cell lung cancer (NSCLC) exhibits a high incidence and mortality rate worldwide. Elevated cytokinesis cyclin 25 homologous protein C (CDC25C) expression is correlated with a poor prognosis in patients with NSCLC. Transcriptional regulation and post‑transcriptional modification are critical mechanisms governing gene expression, with aberrations in these processes increasingly recognized as pivotal contributors to cancer pathogenesis. The present study elucidated that the transcriptional activator, signal transducer and activator of transcription 3, directly interacts with the CDC25C promoter, thereby modulating its expression. Moreover, multi‑omics analysis was employed to identify the genes involved in the N6‑methyladenosine (m

Indexed as

AdenosineCarcinoma, Non-Small-Cell Lungcdc25 PhosphatasesLung NeoplasmsAlkB Homolog 5, RNA DemethylaseCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMethylationPrognosisPromoter Regions, GeneticRNA-Binding ProteinsRNA, MessengerRNA Processing, Post-TranscriptionalAdenosineAlkB Homolog 5, RNA DemethylaseCDC25C protein, humancdc25 PhosphatasesN-methyladenosineRNA-Binding ProteinsRNA, MessengerRNA Splicing FactorsYTHDF2 protein, humanYTHDF3 protein, humanalkB homolog 5 RNA demethylasecytokinesis cyclin 25 homologous protein CN6‑methyladenosinenon‑small cell lung cancerYTH N6‑methyladenosine RNA binding proteins

Identifiers

PMID39981934
PMCPMC11900934

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.