ReviewPhysiological reviews2025
The flux of energy in critical illness and the obesity paradox.
Review in Physiological reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- DXA-Measured Total and Regional Fat-to-Lean Mass Ratio and Mortality Risk in Chinese Older Adults: A 20-Year Prospective Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Article
- The metabolic effects of post-sepsis feeding of meals with only essential amino acids.Clinical science (London, England : 1979) · 2026Article
- Association between anthropometric indices and mortality risk among individuals with depression: A population-based cohort study.The Journal of international medical research · 2026Article
- Combined Impact of Neoadjuvant Therapy and Preoperative Cachexia in Patients Undergoing Pancreatoduodenectomy: Is There a "Double Jeopardy"? A National Cohort Study Investigating the Association with Short- and Long-Term Outcomes.Annals of surgical oncology · 2026Observational
- Joint effects of severe obesity and inflammation on mortality in critically ill non-ST-segment elevation myocardial infarction patients: a cohort study with external validation.Frontiers in endocrinology · 2026Article
- Metabolic and Muscular Determinants of Weaning Failure: The Role of BUN/Creatinine Ratio and Rectus Femoris Thickness.Journal of clinical medicine · 2026Article
- Transitions and determinants of ICU-acquired frailty after critical illness: A multicenter cohort study using a multistate Markov model.Annals of intensive care · 2026Article
- Long-term DNA methylation changes induced by age and elevated COSkeletal muscle · 2025Article
- Association between baseline BMI and in-hospital mortality in critically ill cardiac surgery patients: a retrospective cohort study.European journal of medical research · 2025Article
- Chronic succinate exposure does not cause liver injury.American journal of physiology. Endocrinology and metabolism · 2025Article
- Analysis of the prevalence and risk factors of post-intensive-care syndrome and post-sepsis syndrome in survivors of sepsis.Science progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
During critical illness, systemic inflammation causes organ-specific metabolic changes. In the immune and inflammatory compartments, predominantly anabolic reprogramming supports cellular replication and inflammatory response execution. Pari passu, catabolism of adipose tissue and skeletal muscle supplies carbon skeletons and enthalpy for inflammatory and immune cell anabolism. The liver plays a key role during these metabolic shifts in enabling adequate supply of glucose and ketone bodies to the circulation. Although often perceived as passive surrogates of prehospitalization frailty, body mass constituents are active parties of an overarching metabolic trade-off that is key for survival after acute insults. Muscle and adipose tissue remodel in response to critical illness and thus profoundly influence the systemic metabolic landscape during and after hospitalization. Whether obesity's effect on patient systemic metabolism and survival is paradoxically beneficial or not remains controversial. Substrate-induced epigenetic changes lead to abnormal transcriptional programs that in turn regulate metabolic pathways critical to patient survival. We present a summary of major mechanisms involved in the flux of energy in critical illness from body mass into immune response execution and suggest future research avenues focused on perturbed immune-metabolic and epigenetic programs that could lead to improved understanding of these processes, and eventually to better outcomes for the critically ill.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.