Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity.
Andrew S Lee, Tanzil M Arefin, Alina Gubanova, Daniel N Stephen, Yu Liu, Zhimin Lao, Anjana Krishnamurthy, Natalia V De Marco García, Detlef H Heck, Jiangyang Zhang and 2 more
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Andrew S LeeDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
Tanzil M ArefinBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, USA.
Alina GubanovaDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
Daniel N StephenDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
Detlef H HeckDepartment of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA.
Jiangyang ZhangBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, USA.
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Engrailed genes and cerebellum morphology, spatial gene expression and circuitryR37MH085726 · NIMH · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2014 to 2023
$6.7M
J. NRSA Training CoreTL1TR002386 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Genevieve Giny Fouda Amou ou · 2017 to 2026
$5.8M
Signaling Pathways that Regulate Scaling and Regeneration of the CerebellumR01NS092096 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2015 to 2024
$4.8M
Neural Mechanism for the assembly of GABAergic in the cerebral cortexR01MH110553 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI Natalia Vanesa De Marco Garcia · 2016 to 2026
$4.2M
Training Program in Developmental BiologyT32HD060600 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BAO, ZHIRONG, STUHLMANN, HEIDI · 2010 to 2024
$3.5M
Molecular and circuit defects underlying different SCN2A mutations and ASDsR01MH118934 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI PITT, GEOFFREY S · 2019 to 2023
$3.2M
Quantitative Imaging of Mouse Brain DevelopmentR01NS102904 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZHANG, JIANGYANG · 2018 to 2022
$3.1M
Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memoriesR01DA053261 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Anjali M Rajadhyaksha · 2022 to 2026
$2.6M
A Circuit Mechanism for the Development of Cortico-cortical ConnectivityR01NS116137 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE MARCO GARCIA, NATALIA VANESA · 2020 to 2024
$2.6M
Neuronal mechanisms of cerebellar cognitive functionR01MH112143 · NIMH · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HECK, DETLEF H · 2018 to 2022
$2.3M
GABAergic Interneuron Dysfunction in Developing Cortical Circuits Underlying Autism Spectrum DisordersR01MH125006 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE MARCO GARCIA, NATALIA VANESA, RAJADHYAKSHA, ANJALI M · 2021 to 2025
$2.1M
NCATS NIH HHS TL1 TR002386NCI NIH HHS P30 CA008748NICHD NIH HHS T32 HD060600NIDA NIH HHS R01 DA029122NIDA NIH HHS R01 DA050454NIDA NIH HHS R01 DA053261NIMH NIH HHS R01 MH110553NIMH NIH HHS R01 MH112143NIMH NIH HHS R01 MH118934NIMH NIH HHS R01 MH125006NIMH NIH HHS R37 MH085726NINDS NIH HHS R01 NS092096NINDS NIH HHS R01 NS102904NINDS NIH HHS R01 NS116137U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) T32HD060600U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA08748U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) TL1TR002386U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH110553U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH112143U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH118934U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH125006U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R37MH085726U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS102904U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS116137U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA029122U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA050454
6 · The paper itself
Abstract
The capacity of the brain to compensate for insults during development depends on the type of cell loss, whereas the consequences of genetic mutations in the same neurons are difficult to predict. We reveal powerful compensation from outside the mouse cerebellum when the excitatory cerebellar output neurons are ablated embryonically and demonstrate that the main requirement for these neurons is for motor coordination and not basic learning and social behaviors. In contrast, loss of the homeobox transcription factors Engrailed1/2 (EN1/2) in the cerebellar excitatory lineage leads to additional deficits in adult learning and spatial working memory, despite half of the excitatory output neurons being intact. Diffusion MRI indicates increased thalamo-cortico-striatal connectivity in En1/2 mutants, showing that the remaining excitatory neurons lacking En1/2 exert adverse effects on extracerebellar circuits regulating motor learning and select non-motor behaviors. Thus, an absence of cerebellar output neurons is less disruptive than having cerebellar genetic mutations.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity. · full record | Socratic