Evidence map›Paper›PMID 39984493›Full record

ArticleSchizophrenia (Heidelberg, Germany)2025

Shared genetic architecture and causal relationship between frailty and schizophrenia.

Ming-Gang Deng, Kai Wang, Fang Liu, Xiuxiu Zhou, Jia-Qi Nie, Zhi-Hui Zhao, Jiewei Liu

Abstract read
In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ming-Gang DengDepartment of Psychiatry, Wuhan Mental Health Center, Wuhan, 430012, China. deng.minggang@outlook.com.ORCID http://orcid.org/0000-0002-3154-6909
Kai WangDepartment of Public Health, Wuhan Fourth Hospital, Wuhan, 430000, Hubei, China.
Fang LiuSchool of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, Hubei, China.
Xiuxiu ZhouDepartment of Psychiatry, Wuhan Mental Health Center, Wuhan, 430012, China.
Jia-Qi NieXiaogan Center for Disease Control and Prevention, Xiaogan, 432000, Hubei, China.
Zhi-Hui ZhaoSchool of Nursing, Shanghai Jiao Tong University, Shanghai, 200025, China.
Jiewei LiuDepartment of Psychiatry, Wuhan Mental Health Center, Wuhan, 430012, China. liujiewei@hust.edu.cn.ORCID http://orcid.org/0009-0009-8265-8984

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complex relationship between frailty and schizophrenia has yet to be fully understood. This study aims to clarify their relationship by investigating their genetic links. We hypothesize a shared genetic architecture and a bidirectional causal relationship between the two conditions. Utilizing summary genetic data from European genome-wide association studies, we analyzed genetic associations through global and local correlations, shared genomic loci, tissue enrichments, and functional genes. Bidirectional Mendelian Randomization (MR) was employed to infer causality. Our findings show a positive genetic correlation between frailty and schizophrenia (LDSC: r

Identifiers

PMID39984493
PMCPMC11845589

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.