ArticleNature cell biology2025
Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis.
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Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed.
- Galectin-3 Mediates TGF-β-Controlled Migration in Müller Glial Cells.International journal of molecular sciences · 2026Article
- Synergistic Regulation of Tumor Immunity by Integrins and Lectins: From Molecular Mechanisms to Dual-Targeted Therapy.International journal of molecular sciences · 2026Review
- Functional Specialization of Clathrin-Independent Endocytic Routes: Mechanisms and Cellular Roles.Traffic (Copenhagen, Denmark) · 2026Review
- Cis glycan-glycan interactions organize membrane nanodomains that tune receptor signaling.Nature communications · 2026Article
- From Glycocode to Precision Oncology: Therapeutic Strategies Targeting Aberrant O-GalNAc Glycosylation in Cancer.Chemical reviews · 2026Review
- Caveolae mechanics in cellular functions and disease.Nature reviews. Molecular cell biology · 2026Review
- Expression, Localization and Actions of Galectin-3: Implications in the Pathophysiology and Therapy of Cardiovascular Disease.International journal of molecular sciences · 2026Review
- The ligand preference of LRP1 is regulated by O-glycans.Science advances · 2026Article
- Sialylation in the nervous system: Functions and mechanisms.The Journal of biological chemistry · 2026Review
- From molecular mechanisms of glycosphingolipid function to bio-therapeutic applications.Cellular and molecular life sciences : CMLS · 2026Review
- pH sensing and inflammation: linking acidic microenvironments to immune reprogramming.Frontiers in immunology · 2026Review
- Article
- Ensemble Machine Learning Approaches Predict Survival in Lower-Grade Glioma Based on Glycosphingolipid Gene Expression and Metabolic Modeling.Computational and structural biotechnology journal · 2026Article
- Macropinocytosis fuels osteoclast differentiation in bone-related diseases.Journal of orthopaedic translation · 2025Article
- Spatial N-glycan rearrangement on αNature communications · 2025Article
- Article
- Proteostasis of immune checkpoint receptors.The Biochemical journal · 2025Review
- Galectin-3: Integrator of Signaling via Hexosamine Flux.Biomolecules · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
27 authors.
Ewan MacDonaldCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.
Alison ForresterCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.ORCID http://orcid.org/0000-0003-3352-9173
Cesar A Valades-CruzCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.ORCID http://orcid.org/0000-0002-1786-8207
Thomas D MadsenLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Joseph H R HetmanskiWellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Estelle DransartCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.
Yeap NgLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Rashmi GodboleCellular Organization and Signaling Group, National Centre for Biological Sciences, Bangalore, India.
Ananthan Akhil ShpCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.
Ludovic LeconteSERPICO Project Team, Inria-UMR144 CNRS Institut Curie, PSL Research University, Paris, France.
Valérie ChambonCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.
Debarpan GhoshCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.
Alexis PinetCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.
Dhiraj BhatiaCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.ORCID http://orcid.org/0000-0002-1478-6417
Bérangère LombardCurieCoreTech Spectrométrie de Masse Protéomique, Institut Curie, Université PSL, Paris, France.ORCID http://orcid.org/0000-0001-9044-3662
Damarys LoewCurieCoreTech Spectrométrie de Masse Protéomique, Institut Curie, Université PSL, Paris, France.ORCID http://orcid.org/0000-0002-9111-8842
Martin R LarsenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0001-6203-0123
Hakon LefflerSection MIG (Microbiology, Immunology, Glycobiology), Department of Laboratory Medicine, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0003-4482-8945
Dirk J LefeberDepartment of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Henrik ClausenDepartment for Cellular and Molecular Medicine, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0915-5055
Anne BlangyMontpellier Cell Biology Research Center (CRBM), Université de Montpellier, CNRS, Montpellier, France.ORCID http://orcid.org/0000-0001-7043-0784
Patrick CaswellWellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-2633-2324
Massiullah Shafaq-ZadahCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France.ORCID http://orcid.org/0000-0002-7582-8131
Satyajit MayorCellular Organization and Signaling Group, National Centre for Biological Sciences, Bangalore, India.ORCID http://orcid.org/0000-0001-9842-6963
Roberto WeigertLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. weigertr@mail.nih.gov.ORCID http://orcid.org/0000-0003-0740-4465
Christian WunderCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France. christian.wunder@curie.fr.ORCID http://orcid.org/0000-0001-9091-0080
Ludger JohannesCellular and Chemical Biology Unit, Institut Curie, Université PSL, U1143 INSERM, UMR3666 CNRS, Paris, France. ludger.johannes@curie.fr.ORCID http://orcid.org/0000-0002-2168-0004
Funding
Agence Nationale de la Recherche (French National Research Agency) ANR-10-IDEX-0001-02 PSLAgence Nationale de la Recherche (French National Research Agency) ANR10-INBS-01Agence Nationale de la Recherche (French National Research Agency) ANR-10-INBS-04-07Agence Nationale de la Recherche (French National Research Agency) ANR11-LABX-0038Agence Nationale de la Recherche (French National Research Agency) ANR-11-LABX-0043Agence Nationale de la Recherche (French National Research Agency) ANR-17-CONV-0005Agence Nationale de la Recherche (French National Research Agency) ANR-19-CE13-0001-01Agence Nationale de la Recherche (French National Research Agency) ANR-20-CE15-0009-01Agence Nationale de la Recherche (French National Research Agency) ANR-22-CE11-0030-03Cancer Research UK (CRUK) DCRPGF\100002goLeverhulme Trust LIP-2021-017Mizutani Foundation for Glycoscience (Mizutani Foundation) n°200014Novo Nordisk Fonden (Novo Nordisk Foundation) DNRF107Novo Nordisk Fonden (Novo Nordisk Foundation) NNF0067602Wellcome Trust (Wellcome) 203128/A/16/ZWellcome Trust (Wellcome) 226804/Z/22/Z
Abstract
Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynamic manner remained unexplored. Here we demonstrate that, within minutes, the epidermal growth factor triggers the galectin-driven endocytosis of cell-surface glycoproteins, such as integrins, that are key regulators of cell adhesion and migration. The onset of this process-mediated by the Na
Indexed as
EndocytosisGalectin 3GlycolipidsAnimalsCell MovementGlycosylationGolgi ApparatusHumansHydrogen-Ion ConcentrationMiceN-Acetylneuraminic AcidNeuraminidaseProtein Processing, Post-TranslationalSodium-Hydrogen ExchangersGalectin 3GlycolipidsN-Acetylneuraminic AcidNeuraminidaseSodium-Hydrogen Exchangers
Identifiers
PMID
39984654What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.