Evidence map›Paper›PMID 39984679›Full record

ArticleBritish journal of cancer2025

GDP-bound Rab37 modulates M2-like tumor-associated macrophage polarization by attenuating STAT1 translocation to downregulate the type I IFN pathway.

Chen-Tai Hong, You-En Yang, Hsueh-Fen Juan, Chih-Peng Chang, Yi-Ching Wang

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Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chen-Tai Hong *Department of Pharmacology, College of Medicine, National Cheng Kung University, No.1, University Road, Tainan, 701, Taiwan.
You-En Yang *Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, No.1, University Road, Tainan, 701, Taiwan.ORCID http://orcid.org/0009-0003-1991-4179
Hsueh-Fen JuanDepartment of Life Science, National Taiwan University, No.1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
Chih-Peng ChangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, No.1, University Road, Tainan, 701, Taiwan.ORCID http://orcid.org/0000-0002-0061-3478
Yi-Ching WangDepartment of Pharmacology, College of Medicine, National Cheng Kung University, No.1, University Road, Tainan, 701, Taiwan. ycw5798@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-7694-2067

Funding

Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) MOST 109-2327-B-006-004
6 · The paper itself

Abstract

backgroundTumor-associated macrophages (TAMs) in the tumor microenvironment (TME) primarily polarize into the M2-phenotype. Our previous study showed that the small GTPase Rab37 mediates IL-6 trafficking in macrophages for M2 polarization. Here, we uncover an unconventional role of Rab37, independent of vesicle trafficking, in promoting M2 polarization of TAMs.

methodsThe gene profiles in wild-type and Rab37 knockout (KO) bone marrow-derived macrophages (BMDMs) were analyzed using cDNA microarray. The mechanism of Rab37 in regulating the interferon (IFN) pathway was confirmed through in vitro/vivo assays and clinical studies.

resultsType I IFN signaling was highly enriched in BMDMs from Rab37 KO mice. Moreover, Rab37 induction and decreased type I IFN genes were observed in macrophages treated with lung cancer-conditioned medium and epigenetic drugs, indicating an epigenetic regulation of Rab37 in TAMs. Mechanistically, GDP-bound Rab37 interacted with the nuclear localization sequence of STAT1 to sequest it in the cytosol from its transcription activities, thus leading to the downregulation of IFN genes. Clinically, CD163

conclusionsOur findings highlight the cytosolic interaction of Rab37-STAT1 in M2 TAM polarization, with CD163

Indexed as

Interferon Type ILung Neoplasmsrab GTP-Binding ProteinsSTAT1 Transcription FactorTumor-Associated MacrophagesAnimalsDown-RegulationHumansMiceMice, Inbred C57BLMice, KnockoutSignal TransductionTumor MicroenvironmentInterferon Type Irab GTP-Binding ProteinsSTAT1 protein, humanStat1 protein, mouseSTAT1 Transcription Factor

Identifiers

PMID39984679
PMCPMC11962084

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.