Evidence map›Paper›PMID 39984759›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Expanding the spectrum of FUS::CREM-rearranged neoplasms: a case of mesenchymal malignant tumor with neuroendocrine differentiation.

Mohamed-Amine Bani, Voreak Suybeng, Alexander Valent, Matthieu Faron, Sophie Moog, Abir Al-Ghuzlan, Eric Baudin, Jean-Yves Scoazec

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed-Amine BaniService de Pathologie, Département de Biologie et Pathologie Médicales, Gustave Roussy, 114 Rue Edouard Vaillant, 94805, Villejuif Cedex, France.
Voreak SuybengService de Génétique des Tumeurs, Département de Biologie et Pathologie Médicales, Gustave Roussy, Villejuif, France.
Alexander ValentService de Génétique des Tumeurs, Département de Biologie et Pathologie Médicales, Gustave Roussy, Villejuif, France.
Matthieu FaronDépartement de Chirurgie, Gustave Roussy, Villejuif, France.
Sophie MoogDépartement de Médecine Nucléaire et Oncologie Endocrinienne, Gustave Roussy, Villejuif, France.
Abir Al-GhuzlanService de Pathologie, Département de Biologie et Pathologie Médicales, Gustave Roussy, 114 Rue Edouard Vaillant, 94805, Villejuif Cedex, France.
Eric BaudinDépartement de Médecine Nucléaire et Oncologie Endocrinienne, Gustave Roussy, Villejuif, France.
Jean-Yves ScoazecService de Pathologie, Département de Biologie et Pathologie Médicales, Gustave Roussy, 114 Rue Edouard Vaillant, 94805, Villejuif Cedex, France. jy.scoazec@gmail.com.ORCID http://orcid.org/0000-0003-1604-6823

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report an additional case of FUS::CREM-rearranged neoplasm, with a distinctive clinical presentation and phenotype, in order to expand the spectrum of these tumors and to underline the major issues they raise in diagnosis and classification. A 52-year male patient, with a remote history of seminoma, presented with multiple lung, pancreatic, and renal tumor nodules, containing large nests of medium-sized epithelioid, monomorphic, tumor cells, which did not express any epithelial marker, but expressed all neuroendocrine markers. S100 protein labeled sustentacular-like cells. GATA3 and Phox2B were undetectable; CD99 was strongly positive. ALK was heterogeneously expressed. Ki-67 index ranged from 5 to 15% according to the location. A FUS (exon 7)::CREM (exon 6) fusion was detected in two tumors and confirmed by FISH. This paraganglioma-like malignant neoplasm may belong to the group of FET::CREB-rearranged mesenchymal neoplasms, currently in the course of delineation, and points to its phenotypic diversity.

Indexed as

Cyclic AMP Response Element ModulatorNeuroendocrine TumorsRNA-Binding Protein FUSBiomarkers, TumorGene RearrangementHumansIn Situ Hybridization, FluorescenceLung NeoplasmsMaleMiddle AgedBiomarkers, TumorCREM protein, humanCyclic AMP Response Element ModulatorFUS protein, humanRNA-Binding Protein FUSFUS::CREM fusionMesenchymal neoplasmsNeuroendocrine markersParagangliomaTranslocation

Identifiers

PMID39984759

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.