ArticleBMC rheumatology2025
Effect of gout on 30-day survival in ICU patients: retrospective analysis of a large cohort of critically ill patients.
Article in BMC rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundGout is a chronic disease caused by the deposition of sodium urate crystals, which is prone to multiple comorbidities, especially cardiovascular and kidney diseases. Patients with gout have higher all-cause and cause-specific mortality. However, it is unclear whether gout affects survival in ICU patients.
methodsData of the ICU patient cohort were obtained from the MIMIC IV database. The survival difference between the two groups was compared by Log-rank method. Cox regression was used to estimate the hazard ratio. Possible influencing factors were adjusted by matching. Quantitative variables were compared with Mann-Whitney/Wilcoxon test, and categorical variables were compared with Pearson's Chi-squared test.
resultsThe 30-day survival rate of gout patients in ICU was 87.13%, significantly higher than 84.88% in matched controls (P = 0.009), with hazard ratio (HR) of 0.83 (95% CI: 0.73-0.96). HR was reduced to 0.74 (95% CI: 0.64-0.84) after adjusting Charlson comorbidity Index (CCI) and 0.72 (95% CI: 0.63-0.82) after adjusting sequential organ failure assessment (SOFA). HR rose to 0.86 (95% CI: 0.75-0.98) after matching the first diagnosis, but the difference was still statistically significant (P = 0.029). After grouping matching for sepsis, HR decreased slightly, to 0.80.
conclusionGout showed a protective effect on 30-day survival in ICU patients, indicating that the understanding of gout deserves further exploration.
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