Evidence map›Paper›PMID 39985151›Full record

ArticleExperimental physiology2025

Breath-by-breath measurement of alveolar gas exchange must preserve mass balance and conform to a physiological definition of a breath.

Michele Girardi, Carlo Capelli, Carrie Ferguson, Susan A Ward, Harry B Rossiter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michele GirardiInstitute of Respiratory Medicine and Exercise Physiology, Division of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.ORCID https://orcid.org/0000-0001-8102-7384
Carlo CapelliDepartment of Pathophysiology and Transplants, University of Milano, Milano, Italy.ORCID https://orcid.org/0000-0002-3278-1337
Carrie FergusonInstitute of Respiratory Medicine and Exercise Physiology, Division of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.ORCID https://orcid.org/0000-0001-5235-1505
Susan A WardHuman Bio-Energetics Research Centre, Crickhowell, Wales, UK.
Harry B RossiterInstitute of Respiratory Medicine and Exercise Physiology, Division of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.ORCID https://orcid.org/0000-0002-7884-0726

Funding

Mechanism Underlying the Transduction of Epimutations from the Soma to the Male GermlineP50HD098593 · NICHD · UNIVERSITY OF NEVADA RENO · PI ZHOU, TONG · 2019 to 2024
$7.2M
A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis PatientsR01DK122767 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RHEE, CONNIE MEEYOUNG · 2019 to 2023
$3.3M
Novel cardiopulmonary exercise testing variables to differentiate neuromuscular deconditioning from diseaseR01HL166850 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Harry B Rossiter · 2023 to 2026
$3.1M
COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics ApproachesR01HL153460 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCDONALD DONNELLY, MERRY-LYNN NOELLE · 2021 to 2024
$2.7M
Determinants of 5 Year Progression of Muscle Dysfunction and Inactivity in COPDGene Participants Diversity SupplementR01HL151452 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ADAMI, ALESSANDRA, ROSSITER, HARRY B · 2020 to 2023
$1.6M
Department of Defense/USAMRAA HT9425-24-1-0249Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, ItalyDepartment of Pathophysiology and Transplants, University of Milno, ItalyNHLBI NIH HHS R01 HL151452NHLBI NIH HHS R01 HL153460NHLBI NIH HHS R01 HL166850NICHD NIH HHS P50 HD098593NIDDK NIH HHS R01 DK122767NIH HHS P50HD098593NIH HHS R01DK122767NIH HHS R01HL151452NIH HHS R01HL153460NIH HHS R01HL166850The Regents of the University of California, Tobacco-Related Diseases Research Program T34FT8161Tobacco Related Disease Research Program T31IP1666
6 · The paper itself

Abstract

Tidal breathing in awake humans is variable. This variability causes changes in lung gas stores that affect gas exchange measurements. To overcome this, several algorithms provide solutions for breath-by-breath alveolar gas exchange measurement; however, there is no consensus on a physiologically robust method suitable for widespread application. A recent approach, the 'independent-breath' (IND) algorithm, avoids the complexity of measuring breath-by-breath changes in lung volume by redefining what is meant by a 'breath'. Specifically, it defines a single breathing cycle as the time between equal values of the

Indexed as

Pulmonary AlveoliPulmonary Gas ExchangeRespirationAlgorithmsHumansLungOxygenTidal VolumeOxygenbreathing cycleCPETgas exchangekinetics

Identifiers

PMID39985151
PMCPMC12128475

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.