ArticleBMC geriatrics2025
Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011-2014.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of mobile applications in oral health promotion among elderly people: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Association of frailty and pre-frailty with cardiovascular mortality: a meta-analysis of 26 cohort studies.Frontiers in public health · 2025Pooled it
- Association of Frailty and Its Trajectories With the Risk of Cardiovascular-Kidney-Metabolic Syndrome Progression: A Longitudinal Cohort Study.Geriatrics & gerontology international · 2026Article
- Early-Life Experiences as Moderators of the Relationship Between Extreme Heat and Alcohol Consumption among Older Adults: Quantitative Study.JMIR aging · 2026Article
- Frailty Syndrome and Depressive Symptoms in Patients with Ischemic Heart Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Association of central adiposity indices with cognitive impairment in elderly populations: Development and validation of a risk prediction nomogram using NHANES and CHARLS cohorts.Journal of Alzheimer's disease : JAD · 2026Article
- Associations between cognitive frailty and circulating cardiovascular biomarkers in a memory clinic cohort.GeroScience · 2026Article
- Influencing factors of cognitive frailty in older patients with esophageal cancer undergoing chemotherapy: a mixed-methods study.Frontiers in oncology · 2026Article
- Article
- Anatomically Precise Microsurgical Resection of a Posterior Fossa Cerebellar Metastasis in an Elderly Patient with Preservation of Venous Outflow, Dentate Nucleus, and Cerebrospinal Fluid Pathways.Diagnostics (Basel, Switzerland) · 2025Article
- The heart-brain axis: neurocognitive frailty in heart failure.Journal of neurology · 2025Review
- Frailty and depressive symptoms in relation to cardiovascular disease risk in middle-aged and older adults.Nature communications · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe global aging trend exacerbates the challenge of frailty and cognitive impairment in older adults, yet their combined impact on health outcomes remains under-investigated. This study aims to explore how frailty and psychometric mild cognitive impairment (pMCI) jointly affect all-cause and cardiovascular disease (CVD) mortality.
methodsThe cohort study we examined 2,442 participants aged ≥ 60, is the secondary analysis from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Frailty was quantified using a 49-item frailty index, while pMCI was determined by three composite cognition scores one standard deviation (SD) below the mean. The associations between frailty, pMCI, comorbidity, and mortality were assessed using weighted Cox proportional hazards models.
resultsOf the participants, 31.37% were frail, 17.2% had pMCI, and 8.64% exhibited both conditions. The cohort was stratified into four groups based on frailty and pMCI status. After a median follow-up period of 6.5 years, frail individuals with pMCI had the highest all-cause (75.23 per 1,000 person-years) and CVD (32.97 per 1,000 person-years) mortality rates. Adjusted hazard ratios (HRs) for all-cause (3.06; 95% CI, 2.05-4.56) and CVD (3.8; 95% CI, 2.07-6.96) mortality were highest in frail older adults with pMCI compared to those who were non-frail without pMCI.
conclusionOur study highlights the ubiquity of frailty and cognitive impairment in older adults and underscores the heightened risk of mortality associated with their coexistence. These findings suggest the critical need for proactive screening and management of frailty and cognitive function in clinical practice to improve outcomes for the older adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.