Evidence map›Paper›PMID 39987244›Full record

ArticleCommunications biology2025

Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils.

Stephanie Tullo, Janice Sung Hyun Park, Daniel Gallino, Megan Park, Kristie Mar, Vladislav Novikov, Rodrigo Sandoval Contreras, Raihaan Patel, Esther Del Cid-Pellitero, Edward A Fon and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stephanie TulloIntegrated Program in Neuroscience, McGill University, Montreal, QC, Canada. stephanie.tullo@mail.mcgill.ca.ORCID http://orcid.org/0000-0003-4608-3000
Janice Sung Hyun ParkCerebral Imaging Center, Douglas Research Center, McGill University, Verdun, QC, Canada.ORCID http://orcid.org/0009-0004-3198-9736
Daniel GallinoCerebral Imaging Center, Douglas Research Center, McGill University, Verdun, QC, Canada.
Megan ParkCerebral Imaging Center, Douglas Research Center, McGill University, Verdun, QC, Canada.
Kristie MarCerebral Imaging Center, Douglas Research Center, McGill University, Verdun, QC, Canada.
Vladislav NovikovRobarts Research Institute, Schulich School of Medicine, The University of Western Ontario, London, ON, Canada.
Rodrigo Sandoval ContrerasRobarts Research Institute, Schulich School of Medicine, The University of Western Ontario, London, ON, Canada.ORCID http://orcid.org/0009-0000-1167-2513
Raihaan PatelCerebral Imaging Center, Douglas Research Center, McGill University, Verdun, QC, Canada.
Esther Del Cid-PelliteroDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-8658-944X
Edward A FonDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-5520-6239
Wen LuoEarly Drug Discovery Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-1785-9615
Irina ShlaiferEarly Drug Discovery Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-3737-268X
Thomas M DurcanEarly Drug Discovery Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Marco A M PradoRobarts Research Institute, Schulich School of Medicine, The University of Western Ontario, London, ON, Canada.ORCID http://orcid.org/0000-0002-3028-5778
Vania F PradoRobarts Research Institute, Schulich School of Medicine, The University of Western Ontario, London, ON, Canada.
Gabriel A DevenyiCerebral Imaging Center, Douglas Research Center, McGill University, Verdun, QC, Canada.
M Mallar ChakravartyIntegrated Program in Neuroscience, McGill University, Montreal, QC, Canada. mallar.chakravarty@mcgill.ca.ORCID http://orcid.org/0000-0002-0759-5508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite known sex differences in human synucleinopathies such as Parkinson's disease, the impact of sex on alpha-synuclein pathology in mouse models has been largely overlooked. To address this need, we examine sex differences in whole brain signatures of neurodegeneration due to aSyn toxicity in the M83 mouse model using longitudinal magnetic resonance imaging (MRI; T1-weighted; 100 μm

Indexed as

alpha-SynucleinParkinson DiseaseSynucleinopathiesAnimalsBrainDisease Models, AnimalDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMiceMice, TransgenicSex Factorsalpha-Synuclein

Identifiers

PMID39987244
PMCPMC11846974

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.