Evidence map›Paper›PMID 39987337›Full record

ArticleScientific reports2025

A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population.

Noriko Ohyama, Masatoshi Matsunami, Minako Imamura, Akihiro Yoshida, Azeem Javed, Xiaoxi Liu, Ryosuke Kimura, Koichi Matsuda, BioBank Japan Project, Chikashi Terao and 1 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Noriko OhyamaDepartment of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Masatoshi MatsunamiDepartment of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Minako ImamuraDepartment of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan. mimamura@med.u-ryukyu.ac.jp.
Akihiro YoshidaDepartment of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Azeem JavedDepartment of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Xiaoxi LiuLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Ryosuke KimuraDepartment of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Koichi MatsudaInstitute of Medical Science, The University of Tokyo, Tokyo, Japan.
BioBank Japan Project
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Shiro MaedaDepartment of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Ryukyu archipelago is located southwest of the Japanese islands, and people originally from this region, the Ryukyu population, have a unique genetic background distinct from that of other populations, including people from mainland Japan. However, few genetic studies have focused on the Ryukyu population. In this study, we performed genome-wide association studies (GWAS) on the serum levels of alanine aminotransferase (ALT, n = 15,224), aspartate aminotransferase (AST, n = 15,203), and gamma-glutamyl transferase (GGT, n = 14,496) in the Ryukyu population. We found 13 loci with a genome-wide significant association (P < 5 × 10

Indexed as

Alanine TransaminasePolymorphism, Single NucleotideAdultAsian PeopleAspartate AminotransferasesFemalegamma-GlutamyltransferaseGenome-Wide Association StudyHumansJapanMaleMiddle AgedAlanine TransaminaseAspartate Aminotransferasesgamma-GlutamyltransferaseAlanine aminotransferaseGenome-wide association studyHMMRHMMR-AS1Japanese populationRyukyu population

Identifiers

PMID39987337
PMCPMC11846991

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.