ArticleScientific reports2025
Association between serum vitamin D level and cardiovascular disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Creatinine as a predictor of proliferative diabetic retinopathy among patients with type 2 diabetes mellitus: a systematic review and meta-analysis.International urology and nephrology · 2025Pooled it
- Effect of SGLT-2 inhibitors on COPD exacerbations in individuals with type 2 diabetes: A meta-analysis and Bayesian sensitivity analysis.Journal of diabetes investigation · 2025Pooled it
- Prevalence of vascular complications in Ehlers-Danlos syndrome: a systematic review and meta-analysis.Orphanet journal of rare diseases · 2025Pooled it
- Exploratory Analysis of Type 2 Diabetes Mellitus Metabolic Phenotypes and Their Association With Vitamin D Status in Primary Care Patients.Diabetes, obesity & metabolism · 2026Article
- The Impact of Bariatric Surgery on Obesity-Associated NETosis, Immune Modulation, and Cardiovascular Risk Reduction.Obesity surgery · 2026Review
- Association Between Vitamin D Deficiency and Glycemic, Lipid, and Adiposity Markers in Older Adults: A Nationally Representative Study.Metabolites · 2026Article
- The associations of insomnia symptoms and clinical features as well as blood metabolic parameters in adolescents with major depressive disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
- Article
- Advances and Perspectives in Curcumin Regulation of Systemic Metabolism: A Focus on Multi-Organ Mechanisms.Antioxidants (Basel, Switzerland) · 2026Review
- Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Construction and validation of a risk prediction model for vitamin D deficiency in patients with type 2 diabetes mellitus.Frontiers in nutrition · 2026Article
- Association between serum vitamin D levels and cardiovascular disease risk in patients with hyperuricemia: A cross-sectional study.PloS one · 2026Article
- Association between serum 25-hydroxyvitamin D levels and Early Vascular Aging in young and middle-aged adults.PloS one · 2026Article
- Exploring 1,3,4-oxadiazolyl sulfide derivatives as antidiabetic candidates: synthesis, antioxidant activity, SAR-study, molecular docking, and DFT-insights.BMC chemistry · 2025Article
- Article
- Weight adjusted waist index is a superior obesity index for predicting arterial stiffness in type 2 diabetes mellitus.Scientific reports · 2025Article
- Comparative Pharmacological and Pharmaceutical Perspectives on Antidiabetic Therapies in Humans, Dogs, and Cats.Pharmaceutics · 2025Review
- Tartary Buckwheat Flavonoids and 25-Hydroxyvitamin DAnimals : an open access journal from MDPI · 2025Article
- Synthesis, characterization and antidiabetic studies of novel amantadine-derived Schiff base (AHB) and its Zn(ii), Co(ii), Cr(iii) and VO(iv) complexes.RSC advances · 2025Article
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Abstract
The relationship between 25-hydroxyvitamin D (25(OH)D) status and cardiovascular disease (CVD) in the diabetes population still needs to be clarified. This study aimed to explore the association of 25(OH)D with CVD and cardiometabolic risk factors in Chinese population with type 2 diabetes mellitus (T2DM). This cross-sectional study was performed with 1378 hospitalized patients with T2DM. Participants were classified into three groups according to the serum 25(OH)D levels: vitamin D adequate, vitamin D insufficiency and vitamin D deficient. Multivariate logistic regression analysis, stratified analysis and interaction analysis were performed to determine the relationship between serum 25(OH)D levels and CVD outcome. After adjusting for confounders, serum 25(OH)D levels were significantly negatively associated with cardiovascular disease in type 2 diabetic patients [OR: 0.97 (0.94, 0.99), p = 0.0131]. Taking the vitamin D-sufficient group (≥ 20 ng/mL) as a reference, the vitamin D-deficiency group (< 12 ng/mL) was associated with a significantly higher risk of cardiovascular disease, with a 1.25-fold increased risk after adjusting for all potential confounders [OR: 2.25 (1.33, 3.79), p = 0.0023]. Stratification analysis showed that the association between vitamin D deficiency and increased risk of cardiovascular disease was particularly significant in women [OR: 4.32 (1.54, 12.12), p = 0.0055], older adults [OR: 4.14 (1.10, 15.56), p = 0.0355], normal-weight [OR: 4.09 (1.51, 11.10), p = 0.0056] and obese subjects [OR: 3.66 (1.03, 13.05), p = 0.0453]. Vitamin D deficiency was significantly associated with an increased risk of overweight/obesity [OR: 1.57 (1.10, 2.24), p = 0.0134], hypertension [OR: 1.81 (1.30, 2.51), p = 0.0004], hypertriglyceridemia [OR: 1.56 (1.12, 2.16), p = 0.0078] and reduced HDL-C [OR: 1.67 (1.19, 2.35), p = 0.0033]. Serum 25(OH)D levels were significantly negatively associated with CVD in T2DM patients and vitamin D deficiency was significantly associated with an increased risk of overweight/obesity, hypertension and dyslipidemia.
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