Evidence map›Paper›PMID 39987963›Full record

ArticleContemporary clinical trials2025

Design of a randomized controlled trial to test the efficacy of interrupting sitting on type 2 diabetes risk factors in children with overweight/obesity: The sedentary behavior study 3 protocol.

B R Belcher, K L McAlister, J Zink, T M Chapman, K N Moore, S Castillo, M Hewus, J N Kaslander, C M Dieli-Conwright, J Huh and 1 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

B R BelcherDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, 1845 N. Soto Street, Los Angeles, CA 90032, USA.. Electronic address: bbelcher@usc.edu.
K L McAlisterDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, 1845 N. Soto Street, Los Angeles, CA 90032, USA.. Electronic address: kmcalist@usc.edu.
J ZinkHealth Behaviors Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, MD 20850, USA.. Electronic address: jen.zink.54@gmail.com.
T M ChapmanDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, 1845 N. Soto Street, Los Angeles, CA 90032, USA.. Electronic address: tmchapma@usc.edu.
K N MooreDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, 1845 N. Soto Street, Los Angeles, CA 90032, USA.. Electronic address: knmoore@usc.edu.
S CastilloDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, 1845 N. Soto Street, Los Angeles, CA 90032, USA.. Electronic address: sc_553@usc.edu.
M HewusDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, 1845 N. Soto Street, Los Angeles, CA 90032, USA.. Electronic address: micaelag@usc.edu.
J N KaslanderDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, 1845 N. Soto Street, Los Angeles, CA 90032, USA.. Electronic address: Jonathan.Kaslander@med.usc.edu.
C M Dieli-ConwrightDana-Farber Cancer Institute, 375 Longwood Avenue, the MASCO Building LW743, Boston, MA 02215, USA.. Electronic address: ChristinaM_Dieli-Conwright@dfci.harvard.edu.
J HuhDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, 1845 N. Soto Street, Los Angeles, CA 90032, USA.. Electronic address: jimihuh@usc.edu.
K A PageDivision of Endocrinology, Department of Internal Medicine, Keck School of Medicine of USC, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90089, USA.. Electronic address: katie.page@usc.edu.

Funding

Testing the efficacy of multi-day interruptions in sedentary behaviors on metabolic, cognitive, and affective outcomes in youth at risk for Type 2 diabetesR01DK123333 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · 2023 to 2025
$1.3M
NIDDK NIH HHS R01 DK123333
6 · The paper itself

Abstract

backgroundSedentary behaviors are pervasive in children. We found acute 3-h improvements in metabolic and affective outcomes by interrupting sitting. It is unknown whether acute responses translate to sustained or improved responses over multiple days. This paper describes the rationale, study design, recruitment, data collection, and data analytic protocols for the Sedentary Behavior Study 3 (SBS3).

methodsThis is a 3-arm parallel-group randomized controlled trial of N = 150 (50 per group) 8-11-year-old children with overweight/obesity. Following screening and 7-10 day baseline free-living assessment, children are randomly assigned to complete one of three in-lab conditions for 3 h/day for 7 consecutive days: (1) continuous sitting (SIT); (2) sitting interrupted by 3-min bouts of moderate-intensity walking every 30 min (SIT+WALK); or (3) a single 18-min bout of moderate-intensity walking followed by continuous sitting (EX). Three-hour oral glucose tolerance tests are conducted on Days 1 and 7. Participants also wear continuous glucose monitors and accelerometers for the duration of the study, and complete daily 24-h dietary recalls and affective assessments.

conclusionsThe overall aim of this study is to evaluate the effectiveness of interrupting sitting over one week on glucose homeostasis (primary outcome) and secondary (cognitive and affective) outcomes in children. If successful, it will provide novel intervention strategies that can be translated to other settings, and age and weight groups, thereby contributing to efforts at reducing type 2 diabetes risk in U.S. youth.

trial registrationClinicalTrials.govNCT04469790, registered July 14, 2020.

Indexed as

Diabetes Mellitus, Type 2Pediatric ObesitySedentary BehaviorSitting PositionAccelerometryBlood GlucoseChildExerciseFemaleGlucose Tolerance TestHumansMaleRandomized Controlled Trials as TopicRisk FactorsWalkingBlood GlucoseAffective statesCognitive functionGlucose homeostasisIn-labSedentary behaviorYouth

Identifiers

PMID39987963
PMCPMC11994285

What Socratic holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.