Evidence map›Paper›PMID 39989021›Full record

ArticleActa biochimica et biophysica Sinica2025

KAT8 facilitates the proliferation of cancer cells through enhancing E7 function in HPV-associated cervical cancer.

Anli Xu, Xiaoming Yang, Junwei Zhao, Shujun Kong, Qing Tang, Xiangzhi Li, Hongmei Qu, Guoyun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anli XuDepartment of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
Xiaoming YangDepartment of Gynecology and Obstetrics, Yuhuangding Hospital, Yantai 264000, China.
Junwei ZhaoDepartment of Gynecology and Obstetrics, Yuhuangding Hospital, Yantai 264000, China.
Shujun KongDepartment of Gynecology and Obstetrics, Yuhuangding Hospital, Yantai 264000, China.
Qing TangDepartment of Gynecology and Obstetrics, Yuhuangding Hospital, Yantai 264000, China.
Xiangzhi LiShandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Life Science School of Shandong University, Qingdao 266237, China.
Hongmei QuDepartment of Gynecology and Obstetrics, Yuhuangding Hospital, Yantai 264000, China.
Guoyun WangDepartment of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent human papillomavirus (HPV) infection serves as the principal etiological factor in cervical cancer, with the oncoprotein E7, which is encoded by the virus, playing a key role in tumorigenesis. However, targeted therapeutic strategies against E7 remain underexplored. KAT8, a lysine acetyltransferase, significantly contributes to oncogenesis through the regulation of transcription. However, its involvement in cervical cancer remains inadequately characterized. This study employs HPV18-positive HeLa and HPV16-positive SiHa cell lines to investigate how KAT8 modulates E7 expression and function in cervical cancer cells. Upon

Indexed as

Histone AcetyltransferasesPapillomavirus E7 ProteinsPapillomavirus InfectionsUterine Cervical NeoplasmsAcetylationCell Line, TumorCell ProliferationDNA-Binding ProteinsE2F1 Transcription FactorFemaleGene Expression Regulation, NeoplasticHeLa CellsHuman papillomavirus 16Human papillomavirus 18HumansOncogene Proteins, ViralDNA-Binding ProteinsE2F1 protein, humanE2F1 Transcription FactorE7 protein, Human papillomavirus type 18Histone Acetyltransferasesoncogene protein E7, Human papillomavirus type 16Oncogene Proteins, ViralPapillomavirus E7 ProteinsRetinoblastoma Proteinacetylationcervical cancerE7human papillomavirusKAT8

Identifiers

PMID39989021
PMCPMC12536453

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.